EC Number |
General Information |
Reference |
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1.17.4.2 | metabolism |
RNR is the rate-limiting enzyme in deoxyribonucleoside triphosphate, dNTP, biosynthesis |
716377 |
1.17.4.2 | more |
comparative analyses of ribonucleotide reductase homologs. Results of homology modeling studies indicate that most of the bifidobacteria-specific conserved signature indels are located within the surface loops of the ribonucleotide reductases, and of these, a large 43 amino acid insert in the class III ribonucleotide reductase homolog forms an extension of the allosteric regulatory site known to be essential for protein function. Preliminary docking studies suggest that this large conserved signature indels may be playing a role in enhancing the stability of the RNR dimer complex |
744978 |
1.17.4.2 | more |
cycling fibroblasts from a patient with a lethal mutation in p53R2 contain a normal amount of mtDNA and show normal growth, ribonucleotide reduction, and deoxynucleoside triphosphate (dNTP) pools. However, when made quiescent by prolonged serum starvation the mutant cells strongly down-regulate ribonucleotide reduction, decrease their dCTP and dGTP pools, and virtually abolish the catabolism of dCTP in substrate cycles. mtDNA is not affected |
715583 |
1.17.4.2 | more |
Cys290 in class III from bacteriophage T4 are the conserved cysteine residues that are the sites for generation of the thiyl radical |
715085 |
1.17.4.2 | more |
high-level overexpression of RNR subunits, Rrm1, Rrm2 and p53R2, separately or in different combinations, in mice does not result in mtDNA copy number elevation. Instead, simultaneous expression of two RNR subunits leads to imbalanced dNTP pools and progressive mtDNA depletion in the skeletal muscle, without mtDNA mutagenesis, overview |
716377 |
1.17.4.2 | more |
RNR2Tso2 is essential in Col-0 |
-, 716563 |
1.17.4.2 | more |
RNRs are allosterically regulated on two levels, overall activity and substrate specificity. The substrate specificity is regulated by the binding of dNTPs to the specificity site, ATP and dATP upregulate the reduction of CDP and UDP, whereas dTTP upregulates GDP reduction and dGTP increases the rate of ADP reduction. This regulation is essential to maintain balanced dNTP pools for DNA synthesis and repairI |
716317 |
1.17.4.2 | more |
the class II RNR reaction involves deoxyadenosyl or cysteinyl radicals and is independent of oxygen. The thiyl radical in class II RNR is believed to be generated directly at the active site using the cofactor 5'-deoxyadenosylcobalamin |
715085 |
1.17.4.2 | more |
the class III RNR reaction involves deoxyadenosyl, glycyl, or cysteinyl radicals and requires anaerobic conditions |
715085 |
1.17.4.2 | more |
transcriptional regulation of RNR classes as well as their differential function during infection of macrophage and epithelial cells, overview |
716674 |