EC Number   |
General Information |
Reference |
|---|
   1.14.11.69 | evolution |
enzyme CG15835 shows higher identity to mammalian JMJD2D (40%) than to any of the other mammalian JMJD2 isoforms (22%) |
754921 |
| 1.14.11.69 | evolution |
enzyme CG33182 shows higher identity to mammalian JMJD2D (40%) than to any of the other mammalian JMJD2 isoforms (22%) |
754921 |
| 1.14.11.69 | evolution |
JMJD2A is a JmjC histone demethylase (HDM) |
754871 |
| 1.14.11.69 | evolution |
KDM4A belongs to the KDM4 family |
753167 |
| 1.14.11.69 | evolution |
Rph1 is a histone demethylase containing a Jumonji C (JmjC) domain and belongs to the C2H2 zinc-finger protein family |
-, 726071 |
| 1.14.11.69 | evolution |
the Drosophila melanogaster HDM gene Dmel\Kdm4A is a homologue of the human JMJD2 family. Dmel\JHMD1, Dmel\JHMD2, and Dmel\Kdm4A are each highly conserved with their human homologue counterparts |
753724 |
| 1.14.11.69 | evolution |
the enzyme belongs to the Jmjd2 family of H3K9/H3K36 histone demethylases |
-, 744785 |
| 1.14.11.69 | evolution |
the enzyme belongs to the KDM2-8 family, KDM4 (also known as JMJD2) subfamily, which divided into five isoforms A-E |
744722 |
| 1.14.11.69 | evolution |
the enzyme belongs to the KDM4/JmjC demethylase histone demethylase family. The selectivity of KDM4 enzymes is determined by multiple interactions within the catalytic domain but outside the active site. All KDM4 subfamily members have highly conserved residues lining the methylammonium-binding pocket. The exceptions are Ser288A/Ser-289B/Ser290C and Thr289A/Thr290B/Thr291C in KDM4A, B, and C, which are substituted by Ala287D/Ala289E/Ala286F and Ile288D/Ile290E/Ile287F in KDM4D-F, respectively. Evolutionary analysis of the KDM4 demethylase subfamily |
754098 |
| 1.14.11.69 | evolution |
the enzyme belongs to the KDM4/JmjC demethylase histone demethylase family. The selectivity of KDM4 enzymes is determined by multiple interactions within the catalytic domain but outside the active site. Evolutionary analysis of the KDM4 demethylase subfamily |
754098 |
