EC Number   |
General Information |
Reference |
|---|
   3.1.3.75 | physiological function |
Phospho1-/- mice lack sharp incisal tips, show a 25% increase in total enamel volume, and a 2fold reduction in silver grain density of von Kossa stained ground sections. Phospho1-/- mouse enamel reveals a loss of the prominent enamel prism picket fence structure, a loss of parallel crystal organization within prisms, and a 1.56fold increase in enamel prism width. Phospho1-/- mice display a significant decrease in phosphate incorporation in the enamel layer when compared to controls |
750663 |
| 3.1.3.75 | physiological function |
possible importance of PchP in the pathogenesis of Pseudomonas aeruginosa |
713654 |
| 3.1.3.75 | physiological function |
role of PHOSPHO1 during endochondral ossification, overview |
-, 715704 |
| 3.1.3.75 | physiological function |
transcription of PHOSPHO1 is strongly upregulated during the terminal stages of erythropoiesis, concomitant with increased catabolism of phosphatidylcholine and phosphocholine. Depletion of PHOSPHO1 impairs differentiation of fetal erythroblasts |
750176 |
| 3.1.3.75 | physiological function |
transcription of PHOSPHO1 is strongly upregulated during the terminal stages of erythropoiesis, concomitant with increased catabolism of phosphatidylcholine and phosphocholine. Depletion of PHOSPHO1 impairs differentiation of fetal erythroblasts, and in adult mice depletion impairs phenylhydrazine-induced stress erythropoiesis. Loss of PHOSPHO1 also impairs phosphocholine catabolism in mouse fetal liver progenitors and results in accumulation of several lipids, and ATP production is reduced as a result of decreased oxidative phosphorylation. Glycolysis replaces oxidative phosphorylation in PHOSPHO1 knockout erythroblasts and the increased glycolysis is used for the production of serine or glycine |
750176 |
