EC Number   |
General Information |
Reference |
|---|
    1.1.1.22 | physiological function |
transgenic Arabidopsis lines overexpressing GH_D12G1806 have longer root lengths and higher gene expression level than the wild-type plants of Columbia-0. At flowering stage, the number of trichomes on the sepals of transgenic lines increases significantly, to about 155% of that of the control plants. Compared with the Col-0, most of the trichomes on the main stem of transgenic lines show bifurcated phenotypes |
761138 |
| 1.1.1.22 | physiological function |
UDP-glucose dehydrogenase activity and optimal downstream cellular function require dynamic reorganization at the dimer-dimer subunit interfaces |
740715 |
| 1.1.1.22 | physiological function |
UDP-glucose dehydrogenase is responsible for the NAD-dependent twofold oxidation of UDP-glucose to UDP-glucuronic acid, one of the key components for gellan biosynthesis |
-, 710762 |
| 1.1.1.22 | physiological function |
UDP-glucose dehydrogenase Ugd2 is involved in building capsular polysaccharides K20 and K21. The K20 and K21 capsular polysaccharides include GlcpA produced by Ugd2 and D-galactose with an (R)-configured 4,6-pyruvic acid acetal added by Prt2. The first sugar in the tetrasaccharide K units is 2-acetamido-4-amino-2,4,6-trideoxy-D-glucose (D-QuipNAc4N) that carries a 4-N-[(S)-3-hydroxybutanoyl] group in some K units and a 4-N-acetyl group in the others |
761217 |
| 1.1.1.22 | physiological function |
UGDH is essential in the proteoglycan synthesis in articular chondrocytes, overview |
-, 739967 |
| 1.1.1.22 | physiological function |
UGDH is essential in the proteoglycan synthesis in articular chondrocytes, overview. UDP-glucuronic acid is a key precursor for the synthesis of the glycosaminoglycan chain in proteoglycans |
739967 |
| 1.1.1.22 | physiological function |
UGDH oxidizes UDP-glucose to UDP-glucuronate, an essential precursor for production of hyaluronan, proteoglycans, and xenobiotic glucuronides. High levels of hyaluronan turnover in prostate cancer are correlated with aggressive progression. UGDH expression is high in the normal prostate even though hyaluronan accumulation is virtually undetectable. The enzyme's common role in the prostate may be to provide precursors for glucuronosyltransferase enzymes, which inactivate and solubilize androgens by glucuronidation. Androgen dependence of UGDH, glucuronosyltransferase, and hyaluronan synthase expression, overview |
711665 |
