6.3.2.6 | up |
regulation of both phosphoribosyl amidotransferase (PPAT) and phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), and of pyruvate kinase activity, by L-glutamine, a co-substrate for PPAT. A glutamine antagonist, 6-diazo-5-oxo-L-norleucine (DON) blocks glutamine mediated induction of PPAT and PAICS as well as reduced pyruvate kinase activity, which is completely reversible by addition of L-glutamate |
745942 |