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EC Number Reaction Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.2Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1' - -
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.2Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1' the His-Cys catalytic diad in free papain is fully protonated, -NH(+)/-SH. The experimental pKa of 8.62 for His159 imidazole in free papain is assigned to the -NH(+)/-SH and  -N/-SH equilibrium 710502
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