EC Number |
Reaction |
Reference |
---|
2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
A group of enzymes with differing specificities towards histone acceptors |
- |
2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
acetylation of lysine 5, 8, 12, and 16 of free histone H4 |
487086, 487090, 487093 |
2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
binding motifs |
-, 487102 |
2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
conserved catalytic mechanisms of HATs, overview. p300 utilizes a special type of sequential mechanism with a short-lived ternary complex, known as a Theorell-Chance mechanism |
703350 |
2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
conserved catalytic mechanisms of HATs, overview. p300 utilizes a special type of sequential mechanism with a short-lived ternary complex, known as a Theorell-Chance mechanism. For Gcn5, p/CAF, and p300, only 3 to 5 residues on either side of the substrate lysine are required for efficient binding and catalysis by the catalytic domain |
703350 |
2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
enzymes are also active as transcription coactivators and corepressors of transcription factors in gene regulation, acetylation of transcription factors, overview |
-, 487089 |
2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
mechanisms |
-, 487089, 487090, 487102 |
2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
MORF protein is also active as transcription factor |
487090 |
2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
non-processive mechanism, where the NuA4 histone acetyltransferasecomplex dissociates from substrate after each acetylation event |
718912 |
2.3.1.48 | acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine |
ordered sequential catalytic mechanism of the MYST HAT with a direct-attack mechanism and direct acetyl transfer mechanism, not mediated by Cys304, within an Esa1acetyl-CoAhistone ternary complex, acetyl-CoA binds first and CoA is the last product released |
672263 |