1.1.1.378 | L-rhamnose + NAD(P)+ = L-rhamnono-1,4-lactone + NAD(P)H + H+ |
in putative catalytic mechanism, the C1-OH group of L-rhamnose is deprotonated by Tyr159 as a general basic catalyst, with concurrent transfer of the hydride ion to NAD(P)+, and the pKa value of its hydroxyl group is lowered by Lysl63, leading to the stabilization of the tyrosinate anion at physiological pH |
763033 |