EC Number |
Reaction |
Reference |
---|
1.1.1.169 | (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+ |
- |
- |
1.1.1.169 | (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+ |
molecular catalytic mechanism, substrate and cofactor binding, Asn98, Glu256, and Lys176 are essential, overview |
667687 |
1.1.1.169 | (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+ |
protein-ligand interactions, overview |
669806 |
1.1.1.169 | (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+ |
the enzyme follows a random addition mechanism in which the initial binding of NADPH is the kinetically preferred path, with a small degree of cooperativity between subunits. The mechanism of Staphylococcus aureus KPR is distinct from those of previously described members of the family of 2-hydroxyacid dehydrogenases |
740065 |