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EC Number Posttranslational Modification Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.53sumoylation ROS promotes ALKBH5 sumoylation, which blocks m6A demethylase activity by inhibition of substrate accessibility. Overexpression of sumoylation-deficient ALKBH5 blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis 765485
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