3.5.3.22 | synthesis |
expression of four structural clavulanic acid biosynthesis genes, which encode carboxyethylarginine synthase (Ceas2), beta-lactam synthetase (Bls2), clavaminate synthase (Cas2), and proclavaminate amidinohydrolase (Pah2), in Streptomyces venezuelae enables production of clavulanic acid intermediates deoxygaunidinoproclavaminic acid, guanidinoproclavaminic acid, and dihydroclavaminic acid |
742159 |