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1.1.99.B9
synthesis
coupling of asymmetric oxidation of racemic 2-hydroxyacids with the opposite stereoselective reduction of 2-ketoacids for the stereoselective oxidoreductive deracemization to (R)-2-hydroxyacids, using a one-pot biocatalysis by resting cells of Saccharomyces cerevisiae strain ZJB5074 and Pseudomonas aeruginosa CCTCC M 2011394. Substituted racemic hydroxy(phenyl)acetic acids are converted to (R)-2-hydroxy-2-phenyl acetic acids with 55-98% conversion rate and 99.9% enantiomeric excess
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740300
1.1.99.B9
synthesis
enzyme can be used for the concurrent obtaining of aromatic (R)-2-hydroxyacids and aromatic 2-ketoacids by oxidation of aromatic 2-hydroxyacids in one-step biotransformation
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740783
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