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Results 1 - 3 of 3

EC Number	Natural Substrates	Commentary (Nat. Sub.)
5.4.99.20	23S rRNA uridine2457	-
5.4.99.20	23S rRNA uridine2457	pseudouridine synthase RluE modifies U2457 in a stem of 23S RNA in Escherichia coli. This modification is located in the peptidyl transferase center of the ribosome.The stem alone is not a good RluE substrate, suggesting RluE undergoes additional interactions with other regions in the ribosome
5.4.99.20	more	RluE acts as a stand-alone, highly specific enzyme forming the universally conserved pseudouridine at position 2457, located in helix 89 (H89) of the 23S rRNA in the peptidyltransferase center, detailed structure-function analysis to determine the structural elements both in RluE and in 23S rRNA required for RNA-protein interaction and pseudouridine formation

Results 1 - 3 of 3

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Release 2023.1 (January 2023)