EC Number   |
Natural Substrates |
|---|
    5.1.3.13 | dTDP-4-dehydro-6-deoxy-alpha-D-glucose |
- |
| 5.1.3.13 | dTDP-4-dehydro-6-deoxy-D-glucose |
enzyme in biosynthesis of dTDP-L-dihydrostreptose from dTDP-6-deoxy-D-xylo-4-hexosulose |
| 5.1.3.13 | dTDP-4-dehydro-6-deoxy-D-glucose |
the enzyme is involved in the dTDP-rhamnose synthesis pathway which consists of three steps: (i) the synthesis of dTDP-4-keto-6-deoxy-D-glucose from glucose 1-phosphate and dTDP, (ii) the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-4-keto-L-rhamnose by dTDP-4-dehydrorhamnose 3,5-epimerase and (iii) the reduction of dTDP-4-keto-L-rhamnose to dTDP-L-rhamnose. The mutant K3 strain, with a spontaneous mutation that results in lower cellulose production, shows deoxythymidine diphosphate-4-dehydrorhamnose 3,5-epimerase activity, while the wild-type does not, determined by 2D-gel electrophoresis. It is possible that in the wild-type, transcription of the gene responsible for the expression of dTDP-4-dehydrorhamnose 3,5-epimerase is repressed by a transcription factor, and that a mutation in the gene encoding the transcription factor has rendered it non-functional |
| 5.1.3.13 | dTDP-6-deoxy-D-xylo-4-hexulose |
third enzyme of the rhamnose pathway |
| 5.1.3.13 | more |
the enzyme is required for dTDP-L-rhamnose biosynthesis |
| 5.1.3.13 | more |
third enzyme of dTDP-L-rhamnose pathway |
| 5.1.3.13 | TDP-6-deoxy-D-xylo-4-hexosulose |
enzyme in biosynthesis of the cell wall component 6-deoxy-L-talose |
| 5.1.3.13 | TDP-6-deoxy-D-xylo-4-hexosulose |
enzyme in biosynthesis of dTDP-L-rhamnose from dTDP-D-glucose |
| 5.1.3.13 | TDP-6-deoxy-D-xylo-4-hexosulose |
enzyme is required for biosynthesis of the daunorubicin precursor thymidine diphospho-L-daunosamine |
| 5.1.3.13 | TDP-6-deoxy-D-xylo-hexopyranosid-4-ulose |
conversion of TDP-6-deoxy-D-xylo-hexopyranosid-4-ulose to TDP-L-rhamnose, catalyzed by the two enzymes TDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase, RmlC, and TDP-deoxy-L-lyxo-4-hexulose reductase, RmlD, overview |
