EC Number   |
Natural Substrates |
|---|
   3.4.24.13 | human IgA1 + H2O |
IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 |
| 3.4.24.13 | human immunoglobulin A1 + H2O |
specific cleavage in the hinge region |
| 3.4.24.13 | human immunoglobulin A1 + H2O |
- |
| 3.4.24.13 | human immunoglobulin A1 + H2O |
cleavage of the hinge region |
| 3.4.24.13 | Immunoglobulin A1 + H2O |
- |
| 3.4.24.13 | immunoglobulin IgA1 + H2O |
- |
| 3.4.24.13 | LAMP1 + H2O |
i.e. lysosome-associated membrane protein 1. The enzyme cleaves LAMP1 thereby accelerating its degradation rate in infected A431 human epidermoid carcinoma cells and resulting in the alteration of lysosomes. Infection of T84 monolayers also results in IgA1 protease-mediated reduction of LAMP1 |
| 3.4.24.13 | LAMP1 + H2O |
LAMP1 is a major integral membrane glycoprotein of lysosomes and significantly reduces its steady-state levels in an infected cell. Pilus-induced Ca2+ flux triggers lysosome exocytosis and increases the amount of LAMP1 accessible to IgA1 protease |
| 3.4.24.13 | more |
- |
| 3.4.24.13 | more |
IgA1 protease is an important factor of meningitis |
