EC Number   |
Natural Substrates |
|---|
    2.7.1.6 | ATP + alpha-D-galactose |
- |
| 2.7.1.6 | ATP + galactose |
- |
| 2.7.1.6 | ATP + galactose |
first step in the Leloir pathway for galactose metabolism |
| 2.7.1.6 | ATP + galactose |
galactokinase deficiency is an autosomal recessive disorder, which causes cataract formation in children not maintained on a lactose-free diet |
| 2.7.1.6 | more |
galactokinase Gal1p is a regulator of transcription. Gal1p activates Gal4p, the activator of GAL genes. Gal1p activates Gal4p by direct interaction with the Gal4p inhibitor Gal80p. Interaction requires galactose, adenosine triphosphate and the regulatory function of Gal1p. The gal1p-gal80p complex formation results in the inactivation of Gal80p, thereby transmitting the galactose signal to Gal4p |
| 2.7.1.6 | ATP + galactose |
galaktokinase deficiency is an autosomal recessive disorder characterized by hypergalactosemia and cataract formation |
| 2.7.1.6 | more |
induction of the gal pathway and cellulase genes involves no transcriptional inducer function of the galactokinase in Hypocrea jecorina |
| 2.7.1.6 | ATP + alpha-D-galactose |
involved in Leloir pathway |
| 2.7.1.6 | more |
key enzyme for cellulase induction during growth on lactose |
| 2.7.1.6 | ATP + galactose |
lack of fully functional galactokinase is one cause of the inherited disease galactosemia, the main clinical manifestation of which is the early onset of cataracts |
