EC Number   |
Natural Substrates |
|---|
   2.4.1.221 | GDP-beta-L-fucose + protein |
protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT1 glycosylates epidermal growth factor-like (EGF) repeats within the consensus sequence C2-X-X-X-X-S/T-C3 |
| 2.4.1.221 | GDP-beta-L-fucose + protein |
protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this protein O-fucosylation and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs). PoFUT2 glycosylates thrombospondin type I repeats (TSRs) containing Ser/Thr residues located in the consensus sequences C1-X-X-S/T-C2 or C2-X-X-S/T-C3 of TSRs of groups 1 and 2 |
| 2.4.1.221 | GDP-fucose + TSR4 |
- |
| 2.4.1.221 | GDP-L-fucose + micronemal protein 2 |
- |
| 2.4.1.221 | GDP-L-fucose + Notch protein |
the enzyme fucosylates the epidermal growth factor (EGF)-like domains found in cell-surface and secreted glycoproteins including Notch and its ligands |
| 2.4.1.221 | GDP-L-fucose + transcription regulators DELLA |
O-fucosylation activates DELLA by promoting its interaction with key regulators in brassinosteroid- and light-signaling pathways, including BRASSINAZOLE-RESISTANT1 (BZR1), PHYTOCHROME-INTERACTING-FACTOR3 (PIF3), and PIF4 |
| 2.4.1.221 | more |
enzyme is an essential core member of Notch signaling pathways in mammals |
| 2.4.1.221 | more |
may be involved in intracellular quality control |
| 2.4.1.221 | more |
essential for Notch signaling |
| 2.4.1.221 | more |
POFUT1s bind GDP-fucose and EGF repeats, and transfer this monosaccharide into small EGF repeats producing GDP during the reaction |
