EC Number   |
Natural Substrates |
|---|
    2.3.3.14 | acetyl-CoA + H2O + 2-oxoglutarate |
- |
| 2.3.3.14 | acetyl-CoA + H2O + 2-oxoglutarate |
expression of lys1 is partially repressed by high concentrations of lysine in the culture medium, but lysine repression seems to be a weak mechanism of control of the lysine pathway as compared to lysine inhibition of homocitrate synthase |
| 2.3.3.14 | acetyl-CoA + H2O + 2-oxoglutarate |
the enzyme catalyzes the first step of the lysine and penicillin pathway and is highly sensitive to feedback regulation by L-lysine |
| 2.3.3.14 | acetyl-CoA + H2O + 2-oxoglutarate |
enzymatic formation of homocitric acid, an intermediate in lysine biosynthesis |
| 2.3.3.14 | acetyl-CoA + H2O + 2-oxoglutarate |
first enzyme of the lysine biosynthetic pathway |
| 2.3.3.14 | acetyl-CoA + H2O + 2-oxoglutarate |
the enzyme may play a regulatory function, in addition to its catalytic function, in Saccharomyces cerevisiae but not in Penicillium chrysogenum |
| 2.3.3.14 | acetyl-CoA + H2O + 2-oxoglutarate |
first enzyme of the 2-aminoadipic acid pathway for biosynthesis of lysine |
| 2.3.3.14 | acetyl-CoA + H2O + 2-oxoglutarate |
first enzyme of the lysine biosynthetic pathway, feedback regulated by L-lysine. Maximum homocitrate synthase activity in cultures is found at 48 h, coinciding with the phase of high rate of penicillin biosynthesis |
| 2.3.3.14 | acetyl-CoA + H2O + 2-oxoglutarate |
in the yeast Saccharomyces cerevisiae, the first committed step of the lysine biosynthetic pathway is catalysed by two homocitrate synthases encoded by LYS20 and LYS21. During growth on ethanol, homocitrate is mainly synthesized through Lys21p, while under fermentative metabolism, Lys20p and Lys21p play redundant roles |
| 2.3.3.14 | acetyl-CoA + H2O + 2-oxoglutarate |
the enzyme catalyzes the first and committed step of the alpha-aminoadipate pathway |
