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EC Number Natural Substrates Commentary (Nat. Sub.)
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63DNA (containing 6-O-carboxymethylguanine) + protein L-cysteine -
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63DNA (containing 6-O-methylguanine) + protein L-cysteine -
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63DNA (containing 6-O-methylguanine) + [protein] L-cysteine the DNA repair protein O6-alkylguanine-DNA alkyltransferase is a principal mechanism of cellular resistance to the toxic and mutagenic effects of DNA damage produced by certain monofunctional alkylating agents. ATase operates by the transfer of the offending alkyl groups from the O6 position of guanine and the O4 position of thymine in damaged DNA to a cysteine residue at the active site of the protein. This is an irreversible process that results in the stoichiometric inactivation of the protein
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63DNA (containing 6-O-methylguanine) + [protein] L-cysteine -
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63DNA (containing 6-O-methylguanine) + [protein]-L-cysteine -
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63DNA (containing O6-chloroethylguanine) + protein L-cysteine -
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63DNA (containing O6-[4-oxo-4-(3-pyridyl)butyl]guanine) + protein L-cysteine -
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63DNA containing 4-O-methylthymine + [protein-L-cysteine DNA-repair enzyme
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63DNA containing 4-O-methylthymine + [protein-L-cysteine enzyme repairs O6-methylguanine lesions in DNA via alkyl transfer action
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.63DNA containing 6-O-methylguanine + [protein]-L-cysteine -
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