EC Number   |
Natural Substrates |
|---|
   1.14.14.25 | cholesterol + NADPH + O2 |
the enzyme is important in cholesterol metabolism in the brain, cholesterol dynamics in the fetal and neonatal brain, overview |
| 1.14.14.25 | cholesterol + NADPH + O2 |
the enzyme is important in cholesterol metabolism in the brain, overview |
| 1.14.14.25 | cholesterol + NADPH + O2 |
the enzyme is responsible for cholesterol elimination from brain, (24S)-hydroxycholesterol can cross the blood-brain barrier, enter the circulation, and then be delivered to the liver for further degradation, cholesterol metabolism, overview, CYP46A1 may participate in metabolism of neurosteroids and drugs that are targeted to the central nervous system |
| 1.14.14.25 | cholesterol + reduced adrenodoxin + O2 |
- |
| 1.14.14.25 | cholesterol + reduced adrenodoxin + O2 |
enzyme deficiency leads to a suppression of the mevalonate pathway and a defect in learning |
| 1.14.14.25 | cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 |
- |
| 1.14.14.25 | cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 |
24-hydroxylation represents an important pathway by which cholesterol is secreted from the brain. The enzyme contributes little to overall bile acid synthesis but is important in the turnover of cholesterol in the brain |
| 1.14.14.25 | cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 |
cholesterol 24-hydroxylase constitutes a major tissue-specific pathway for cholesterol turnover in the brain |
| 1.14.14.25 | cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 |
initiates cholesterol degradation in the brain. In addition to the involvement in cholesterol homeostasis in the brain, this enzyme may participate in metabolism of neurosteroids and drugs that can cross the blood-brain barrier and are targeted to the central nervous system |
| 1.14.14.25 | cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 |
24-hydroxycholesterol induces, through the liver X receptor, activation of genes involved in cholesterol efflux, including the ATP-binding cassette transporter A1 and apolipoprotein E, overview |
