EC Number |
Natural Substrates |
---|
2.7.11.16 | ATP + ATP + G protein-coupled receptor |
- |
2.7.11.16 | ATP + protein p105 |
- |
2.7.11.16 | ATP + rhodopsin |
- |
2.7.11.16 | ATP + [G protein-coupled receptor] |
- |
2.7.11.16 | ATP + [G-protein-coupled receptor] |
- |
2.7.11.16 | more |
arrestin-2 and GRK5, not GRK6, interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages, overview |
2.7.11.16 | ATP + beta-adrenergic receptor |
desensitization of the receptor by GRK4, GRK5, and GRK6 |
2.7.11.16 | ATP + central M2 muscarinic receptor |
desensitization of the receptor by GRK5, GRK5 regulates pulmmonary responses by activation of the airway receptor, but does not regulate the peripheral cardiac muscarinic receptors |
2.7.11.16 | ATP + dopamine D1 receptor |
dopamine D1 receptors in IEC-6 rapidly desensitize to D1-like agonist stimulation and GRK 6 isozymes A and B, but not GRK 4, appear to be involved in agonist-mediated responsiveness and desensitization |
2.7.11.16 | more |
enzyme is involved in fertilization |