EC Number   |
Natural Substrates |
|---|
    4.3.2.2 | adenylosuccinate |
- |
| 4.3.2.2 | more |
the low activity of the enzyme in liver of severely starved rats is inconsistent with the proposal that the purine nucleotide cycle plays a major role in ammonia production for urea synthesis at least under these conditions |
| 4.3.2.2 | more |
roles of adenylosuccinate lyase and of AMP deaminase in the anti-HIV activity of 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine |
| 4.3.2.2 | more |
adenylosuccinate lyase catalyzes two reactions in the biosynthesis of purine nucleotides |
| 4.3.2.2 | more |
adenylosuccinate lyase deficiency is a rare autosomal disorder of de novo purine synthesis, which results in the accumulation of succinylpurines in body fluids. Patients with adenylosuccinate lyase deficiency show a variable combination of mental retardation, epilepsy and autistic features, overview |
| 4.3.2.2 | more |
adenylosuccinate lyase deficiency is an autosomal recessive disorder of the purine de novo synthesis pathway and purine nucleotide cycleby severe neurological involvement including hypotonia, seizures, developmental delay and autistic features. Epilepsy in ADSL deficiency is frequent and occurs in approximately two-thirds of patients, beginning either early in the neonatal period or after the first year of life |
| 4.3.2.2 | more |
adenylosuccinate lyase is the only enzyme in the purine biosynthetic pathway that catalyzes two distinct, but chemically similar reactions |
| 4.3.2.2 | more |
ZMP is an activator of the AMP-activated protein kinase, AMPK, and is toxic in human B lymphocytes and neuroblastoma cell lines, physiological functions of ZMP, overview |
| 4.3.2.2 | more |
the activity of the Mycobacterium tuberculosis enzyme is particularly low |
| 4.3.2.2 | N6-(1,2-dicarboxyethyl)AMP |
- |
