EC Number   |
Natural Substrates |
|---|
   3.4.22.38 | collagen I + H2O |
inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice, overview |
| 3.4.22.38 | Protein + H2O |
involved in bone resorption, hydrolysis of proteinaceous bone matrix in the process of remodeling of the human skeleton |
| 3.4.22.38 | more |
media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview |
| 3.4.22.38 | collagen I + H2O |
osteoclasts degrade bone matrix by demineralization followed by degradation of type I collagen through secretion of the cysteine protease, cathepsin K |
| 3.4.22.38 | Protein + H2O |
remodeling of extracellular bone matrix, together with other collagenolytic and gelatinolytic enzymes |
| 3.4.22.38 | chemo-attractant stromal-derived factor-1alpha + H2O |
the enzyme cleaves chemo-attractant stromal-derived factor-1alpha (SDF-1alpha) at 3 sites in the N-terminus, which is the region of SDF-1alpha that binds to its receptors |
| 3.4.22.38 | more |
the enzyme may play a role in tumor progression, coculture of CTSK+ fibroblasts enhances the invasion of CTSK-breast tumor epithelial cells, whichis blocked by CTSK inhibitors, overview |
| 3.4.22.38 | collagen I + H2O |
the lysosomal cysteine protease cathepsin K plays a key role in the degradation of the bone matrix, Cat K deficiency leads to an increase in bone mineral density |
| 3.4.22.38 | kinin + H2O |
the potency of cathepsin K to modulate bradikinin-dependent contraction of smooth muscles, cathepsin K may act as a kininase |
| 3.4.22.38 | Elastin + H2O |
the preferred cleavage site is at Pro-Xaa-Gly |
