EC Number   |
Natural Substrates |
|---|
    3.1.4.17 | more |
PDE1A is involved in cGMP breakdown in parotid acinar cells of Oryctolagus cuniculus |
| 3.1.4.17 | more |
PDE1A_v7 is the major form of cyclic nucleotide phosphodiesterase 1A expressed in mature sperm and is therefore likely to play an important role in cyclic nucleotide regulation of mature sperm function |
| 3.1.4.17 | more |
real-time monitoring of PDE2 activity by a fluorescent cAMP sensor shows that activation of PDE2 results in a rapid decrease of intracellular cAMP from high micromolar to sub-micromolar range within a few seconds. High catalytic activity and fast action in regulating cAMP signaling in a physiological system |
| 3.1.4.17 | more |
Rv0805 protein could have an important role to play in regulating cAMP levels in Mycobacterium tuberculosis |
| 3.1.4.17 | more |
the enzyme might be involved in multiple physiological processes in various organs via its ability to modulate intracellular cAMP and cGMP levels |
| 3.1.4.17 | more |
cGMP levels in the spinal cord are controlled by a number of enzyme isoforms, that can be present in the same cell. Role of NO-cGMP signaling in nociceptive processing |
| 3.1.4.17 | more |
cytoplasmic isoform PDE1A regulates myosin light chain phosphorylation with little effect on apoptosis, whereas nuclear enzyme isoform PDE1A is important in vascular smoth muscle cell growth and survival |
| 3.1.4.17 | more |
isoform PDE1B2 predominantly regulates cGMP and plays a lesser role in cAMP regulation in response to cyclase agonists |
| 3.1.4.17 | more |
isoform PDE2 regulates the basal cGMP concentration in thalamic neuron |
| 3.1.4.17 | more |
the effect of increasing concentrations of cGMP on endothelial permeability is biphasic, attributable to the relative amounts of enzyme isoforms PDE2A and PDE3A in endothelial cells |
