EC Number |
Natural Substrates |
---|
1.8.1.9 | thioredoxin + NADP+ |
reduction of free radicals at the surface of the epidermis, enzyme may play a role in physiology of pancreatic beta-cells |
1.8.1.9 | thioredoxin + NADP+ |
major anti-oxidant in keratinocytes, melanocytes, melanoma cells |
1.8.1.9 | thioredoxin + NADP+ |
the enzyme forms a redox system with protein-disulfide oxidoreductase PhRP (PH0178) |
1.8.1.9 | thioredoxin 1 + NADP+ |
TrxR2 prefers its endogenous substrate thioredocin 2 over thioredoxin 1 (10fold), whereas isoform TrxR1 efficiently reduces both thioredoxin 1 and thioredoxin 2 |
1.8.1.9 | thioredoxin 1 + NADP+ + |
- |
1.8.1.9 | thioredoxin 2 + NADP+ |
- |
1.8.1.9 | thioredoxin 2 + NADP+ |
TrxR2 prefers its endogenous substrate thioredocin 2 over thioredoxin 1 (10fold), whereas isoform TrxR1 efficiently reduces both thioredoxin 1 and thioredoxin 2 |
1.8.1.9 | thioredoxin 3 + NADP+ |
- |
1.8.1.9 | thioredoxin disulfide + H2 |
- |
1.8.1.9 | thioredoxin disulfide + NADH + H+ |
- |