EC Number   |
Natural Substrates |
|---|
    1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
isozyme TPH2 is the rate-limiting enzyme in serotonin/5-hydroxytryptamine biosynthesis |
| 1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
key enzyme of serotonin synthesis in the brain is tryptophan hydroxylase-2 |
| 1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
low tryptophan levels are associated with depression and may arise because of stress, the hypothalamic and peripheral serotonin, i.e.5-hydroxytryptamine-system has a significant role in appetite regulation, possibly a homeostatic mechanism in regulating peripheral TRP levels, overview |
| 1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
rate-limiting enzyme in serotonin biosynthesis, mice deficient in peripheral tryptophan hydroxylase and serotonin exhibit a reduced risk of thrombosis and thromboembolism |
| 1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
rate-limiting enzyme in serotonin synthesis |
| 1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
rate-limiting step in serotonin, i.e. 5-hydroxytryptamine, biosynthesis |
| 1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
rate-limiting step in the biosynthesis of serotonin, regulation of isozymes TPH1 and TPH2, overview |
| 1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
rate-limiting step in the synthesis of serotonin |
| 1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
the calcium influx through L-type high voltage-activated calcium channels is essential for the full activation of tryptophan hydroxylase leading to melatonin synthesis in the pineal gland |
| 1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
the enzyme is involved in emotional responses |
