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EC Number
Metals/Ions
Commentary
Reference
3.4.22.70
Ca2+
2 mM, 8fold stimulation of activity, binding near the active site stimulates catalysis possibly by altering the conformation of a surface loop that recognizes newly translocated polypeptides
647380
3.4.22.70
Ca2+
a single Ca2+ bound to an ordered pocket on SrtA allosterically activates catalysis by modulating both the structure and dynamics of a large active site loop
665718
3.4.22.70
Ca2+
required
731266
,
731478
,
732168
3.4.22.70
Mg2+
can substitute in part for Ca2+
647380
3.4.22.70
Mn2+
can substitute in part for Ca2+
647380
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