EC Number   |
Inhibitors |
Structure |
|---|
    4.1.3.4 | (-)-epicatechin gallate |
a mixed-type noncompetitive inhibitor |
   |
| 4.1.3.4 | (-)-epigallocatechin |
a mixed-type noncompetitive inhibitor |
|
| 4.1.3.4 | (-)-epigallocatechin gallate |
a mixed-type noncompetitive inhibitor, contribution of the gallyl moiety, which forms a hexa-coordination complex with the Mg2+ ion, to enzymatic inhibition |
|
| 4.1.3.4 | (R)-3-hydroxy-3-methylglutaryl-CoA |
- |
|
| 4.1.3.4 | 1,10-phenanthroline |
43% activity after 4 h at 4 mM |
|
| 4.1.3.4 | 2-butynoyl-CoA |
active-site inhibition, only recombinant wild-type, not C237 mutants, indication of active-site directed mutagenesis |
|
| 4.1.3.4 | 2-butynoyl-CoA |
sensitivity to inactivation depends on redox state of enzyme, Kinact: 0.22 min-1, reduced, 0.03 min 1, oxidized |
|
| 4.1.3.4 | 3-hydroxyglutaryl-CoA |
Ki: 0.05 mM, Ki of acetyl-CoA enolization: 0.095 mM |
|
| 4.1.3.4 | 3-hydroxyglutaryl-CoA |
competitive; competitive inhibitor |
|
| 4.1.3.4 | 3-hydroxyglutaryl-CoA |
competitive inhibitor |
|
