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EC Number
Inhibitors
Commentary
Structure
3.1.8.2
2-hydroxyquinoline
a specific reversible competitive inhibitor of h-PON1 that is known to bind in the active site of the enzyme and inhibit the hydrolytic activities of the enzyme
3.1.8.2
Acetylcholine
high concentration
3.1.8.2
Butyrylcholine
high concentration
3.1.8.2
Ca2+
weak
3.1.8.2
Ca2+
-
3.1.8.2
Cu2+
-
3.1.8.2
EDTA
-
3.1.8.2
EDTA
inhibits wild-type and mutant enzymes at 50 mM
3.1.8.2
EGTA
only slightly by Fe3+ or Ni2+, not by Cs2+, Cu2+, Mg2+, Ca2+ or Zn2+; reversible by Mn2+ or Co2+
3.1.8.2
EGTA
Mn2+ reverses and stimulates over pre-EGTA-treatment activity level, Co2+ partially restores; reversible by Mn2+ or Co2+; strong
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