EC Number |
Inhibitors |
Structure |
---|
2.1.1.103 | (3S)-1-(4-hydroxyphenyl)-N-[(2S)-1-[[2-(1H-indol-3-yl)ethyl]amino]-1-oxopropan-2-yl]-5-oxopyrrolidine-3-carboxamide |
i.e. ZINC12882412. Compound has good druglike properties and affinity for Pmt and inhibits Plasmodium falciparum growth with IC50 value of 2.1 microM. It is nontoxic in vitro against HEK-293 cells |
|
2.1.1.103 | 7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione |
i.e. NSC-668394 |
|
2.1.1.103 | amodiaquine |
complete inhibition at 0.025 mM |
|
2.1.1.103 | amodiaquine |
i.e. 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol |
|
2.1.1.103 | amodiaquine |
- |
|
2.1.1.103 | Chloroquine |
- |
|
2.1.1.103 | Co2+ |
- |
|
2.1.1.103 | diphenhydramine |
i.e. 2-(diphenylmethoxy)-N,N-dimethylethanamine |
|
2.1.1.103 | dodecyltrimethylammonium |
25% inhibition at 0.5 mM |
|
2.1.1.103 | hexadecyltrimethylammonium |
about 50% inhibition at 0.1 mM |
|