EC Number   |
Inhibitors |
Structure  |
|---|
    4.3.2.2 | virazole 5'-phosphate |
- |
   |
| 4.3.2.2 | adenyloethylphosphonate |
- |
|
| 4.3.2.2 | adenosine phosphonobutyric, 2'(3'), 5'-diposphate |
- |
|
| 4.3.2.2 | ammonium salt of N6-malonyl adenosine 5'-phosphate |
noncompetitive inhibitor, irreversible |
|
| 4.3.2.2 | N-(5-amino-1-(beta-D-ribofuranosyl)imidazole-4-carbonyl)-L-threo-beta-methylaspartic acid 5'-phosphate |
- |
|
| 4.3.2.2 | N6-(L-1,3-dicarboxyprop-1-yl)-AMP |
i.e. adenyloglutarate |
|
| 4.3.2.2 | nitroacrylate |
0.02 mM, 70% inactivation |
|
| 4.3.2.2 | phosphopropionoadenosine |
- |
|
| 4.3.2.2 | 5-aminoimidazole-4-carboxamide riboside 5'-monophosphate |
i.e. ZMP or AICAR, product inhibition, accumulation in the brain of Lesch-Nyhan disease patients induces inhibition of mitochondrial oxidative phosphorylation and adenylosuccinate lyase activity, followed by dowregulation of ATP levels and multifocal cell death in the cerebellum |
|
