EC Number   |
Inhibitors |
Structure |
|---|
    1.1.1.21 | (10-benzyl-3,4-dioxo-3,4-dihydro[1,2,4]triazino[4,3-a]benzimidazol-2(10H)-yl)acetic acid |
- |
   |
| 1.1.1.21 | (1H-indol-1-yl)acetic acid |
- |
|
| 1.1.1.21 | (2,3-dihydrocyclopenta[b]indol-4(1H)-yl)acetic acid |
- |
|
| 1.1.1.21 | (2,4-dioxo-5-[(6,8-dimethyl-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl) acetic acid |
- |
|
| 1.1.1.21 | (2,4-dioxo-5-[(6-isopropyl-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl) acetic acid |
- |
|
| 1.1.1.21 | (2,4-dioxo-5-[(6-methyl-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl)acetic acid |
- |
|
| 1.1.1.21 | (2,4-dioxo-5-[(6-nitro-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl)acetic acid |
- |
|
| 1.1.1.21 | (2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid |
an aldose reductase inhibitor and antioxidant of zwitterionic nature |
|
| 1.1.1.21 | (2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-yl)-acetic acid |
uncompetitive with both D,L-glyceraldehyde and NADPH |
|
| 1.1.1.21 | (2-carbamoyl-5-fluorophenoxy)acetic acid |
the carboxamide nitrogen can undergo a further H-bond to the additionally recruited water molecule W2 that in turn mediates H-bonded contacts involving the additional water molecule W3 to the amide bonds next to Leu300. Using water molecules W2 and W3 as mediating partners, the compound forms additional polar contacts to the protein |
|
