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General Stability
Reference
3.5.4.38
the enzyme displays a different stability depending on the specific cell compartment in which it is located. In a Burkitts lymphoma cell line the half-life of activation-induced cytidine deaminase is markedly reduced in the nucleus. This destabilization is accompanied by a polyubiquitination that is revealed in the presence of proteasome inhibitors. The same compartment-specific degradation is observed in activated mouse B cells, and also in a nonB cell line
720140
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