EC Number   |
Activating Compound |
Reference |
|---|
   2.7.1.154 | A23187 |
Ca2+-ionophore, activates enzyme form PI3K-C2beta, mimicks hepatocyte growth factor HGF |
660945 |
| 2.7.1.154 | growth factors |
addition of serum to growth-factor-deficient medium increases PI3K-C2alpha expression |
660899 |
| 2.7.1.154 | hepatocyte growth factor HGF |
in renal brush-border and basal lateral plasma membranes, in the latter case mediated by calpain |
660945 |
| 2.7.1.154 | Insulin |
- |
645036, 660899 |
| 2.7.1.154 | ITSN1 |
a PI3KC2beta activator |
761670 |
| 2.7.1.154 | ITSN1 |
endogenous ITSN1 is required for the formation of actin patches and recruitment of PI3K-C2beta to the clathrin-coated structures |
761736 |
| 2.7.1.154 | leptin |
4fold activation of class II isoform PI3K-C2beta by activation of the ERK pathway, no recruitment of tyrosine phosphorylated proteins to the isozyme, blockade of activation by MEK-inhibitor PD98059 |
645036 |
| 2.7.1.154 | lysophosphatidic acid |
activates PI3KC2beta in SKOV3 cells |
761670 |
| 2.7.1.154 | monocyte chemotactic peptide-1 |
agonist-induced activation |
640921 |
| 2.7.1.154 | more |
interaction with Grb2 dramatically increases catalytic activity. Proline-rich motifs within the N-terminus of PI3K-C2beta mediate the association of this enzyme with activated EGF receptor and this interaction involves the Grb2 adaptor |
645045 |
