EC Number   |
Activating Compound |
Reference |
|---|
   2.7.1.153 | beta-catenin |
tyrosine-phopshorylated |
708568 |
| 2.7.1.153 | c-Src |
- |
708568 |
| 2.7.1.153 | cAMP |
PI 3-kinase is activated in response to cAMP or IGF-I, the PI 3-kinase activity bound to its p85 regulatory subunit increases by 1.7fold. cAMP-dependent PI 3-kinase activation plays an important role in the increase in cyclin D1 translation. In contrast, IGF-I-dependent PI 3-kinase activation is required for the increase in cyclin D1 mRNA levels and degradation of p27Kip1 |
708336 |
| 2.7.1.153 | Dlg |
tyrosine-phopshorylated |
708568 |
| 2.7.1.153 | G-protein alpha, beta and gamma subunit |
strong |
640916 |
| 2.7.1.153 | G-protein beta,gamma |
in vivo, activation of enzyme by a mechanism assigning specific roles for both enzyme subunits, membrane recruitment via the noncatalytic p101 subunit, and direct stimulation of p110gamma |
662493 |
| 2.7.1.153 | G-protein beta,gamma subunit |
purified from bovine brain, 16fold activitation at 0.016 mM |
662910 |
| 2.7.1.153 | G-protein beta,gamma subunits |
significant stimulation of enzyme beta and gamma isoforms in the presence as well as in the absence of non-catalytic subunits such as p85alpha or p101, stimulation of autophosphorylation of the catalytic subunit of enzyme |
662104 |
| 2.7.1.153 | guanosine 5'-3-O-(thio)triphosphate |
up to 3fold increase in activity, activation is blocked by high concentrations of guanosine-5-2-O-(thio)diphosphate |
662910 |
| 2.7.1.153 | IGF-I |
PI 3-kinase is activated in response to cAMP or IGF-I. cAMP-dependent PI 3-kinase activation plays an important role in the increase in cyclin D1 translation. In contrast, IGF-I-dependent PI 3-kinase activation is required for the increase in cyclin D1 mRNA levels and degradation of p27Kip1 |
708336 |
