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Literature summary extracted from

  • Walsh, C.T.
    Enzymes in the D-alanine branch of bacterial cell wall peptidoglycan assembly (1989), J. Biol. Chem., 264, 2393-2396.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
5.1.1.1 additional information
-
 Geobacillus stearothermophilus
5.1.1.1 additional information double mutant for the alr encoded enzyme and the dad B encoded enzyme display a phenotype of requirement for exogenous D-Ala for growth Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.1.1 additional information Salmonella enterica subsp. enterica serovar Typhimurium alr racemase is constitutive and serves an anabolic function, dadB encoded enzyme is inducible and required for cell growth on L-Ala ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.1.1.1 Escherichia coli
-
-
-
5.1.1.1 Geobacillus stearothermophilus
-
-
-
5.1.1.1 Salmonella enterica subsp. enterica serovar Typhimurium
-
 encoded by alr and dadB gene
-
5.1.1.1 Staphylococcus sp.
-
-
-
6.3.2.10 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.1.1 L-Ala
-
 Salmonella enterica subsp. enterica serovar Typhimurium D-Ala
-
 ?
5.1.1.1 L-Ala
-
 Escherichia coli D-Ala
-
 ?
5.1.1.1 L-Ala
-
 Geobacillus stearothermophilus D-Ala
-
 ?
5.1.1.1 L-Ala
-
 Staphylococcus sp. D-Ala
-
 ?
5.1.1.1 additional information alr racemase is constitutive and serves an anabolic function, dadB encoded enzyme is inducible and required for cell growth on L-Ala Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
6.3.2.10 ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala
-
 Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala
-
 ?
6.3.2.10 ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + fluoro-D-Ala-fluoro-D-Ala
-
 Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-fluoro-D-Ala-fluoro-D-Ala
-
 ?

Subunits

EC Number Subunits Comment Organism
5.1.1.1 dimer
-
 Geobacillus stearothermophilus
5.1.1.1 monomer
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.3.2.10 additional information
-
 additional information
-
 Escherichia coli