Literature summary extracted from

Vessey, D.A.; Benfatto, A.M.
Chemical modification of bile acid: CoA ligase (1993), Biochim. Biophys. Acta, 1203, 126-130.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
6.2.1.7	NEM	biphasic effect: at short reaction times ligase activity increases, but further reaction leads to nearly complete inactivation	Cavia porcellus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
6.2.1.7	diacetyl	inactivation by modification of arginine residues, ATP protects	Cavia porcellus
6.2.1.7	NEM	biphasic effect: at short reaction times ligase activity increases, but further reaction leads to nearly complete inactivation	Cavia porcellus
6.2.1.7	Phenylglyoxal	inactivation by modification of arginine residues, ATP protects	Cavia porcellus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
6.2.1.7	microsome	-	Cavia porcellus	-	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.2.1.7	Cavia porcellus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
6.2.1.7	liver	-	Cavia porcellus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.2.1.7	ATP + cholate + CoA	-	Cavia porcellus	AMP + diphosphate + choloyl-CoA	-	?

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Release 2023.1 (January 2023)