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Literature summary extracted from

  • Zhou, S.; Pan, J.; Davis, K.M.; Schaperdoth, I.; Wang, B.; Boal, A.K.; Krebs, C.; Bollinger, J.M.
    Steric enforcement of cis-epoxide formation in the radical C-O-coupling reaction by which (S)-2-hydroxypropylphosphonate epoxidase (HppE) produces fosfomycin (2019), J. Am. Chem. Soc., 141, 20397-20406 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.11.1.23 F182A the variant favors trans-fosfomycin production from (S)-2-hydroxypropylphosphonate Streptomyces wedmorensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.23 (S)-2-hydroxypropylphosphonate + H2O2 Streptomyces wedmorensis
-
 cis-fosfomycin + trans-fosfomycin + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.23 Streptomyces wedmorensis Q56185
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.23 (S)-2-hydroxypropylphosphonate + H2O2
-
 Streptomyces wedmorensis cis-fosfomycin + trans-fosfomycin + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.23 (S)-2-hydroxypropylphosphonate epoxidase
-
 Streptomyces wedmorensis
1.11.1.23 HppE
-
 Streptomyces wedmorensis

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.1.23 heme
-
 Streptomyces wedmorensis