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Literature summary extracted from

  • Nilsson, I.; Grove, K.; Dovala, D.; Uehara, T.; Lapointe, G.; Six, D.A.
    Molecular characterization and verification of azido-3,8-dideoxy-D-manno-oct-2-ulosonic acid incorporation into bacterial lipopolysaccharide (2017), J. Biol. Chem., 292, 19840-19848 .
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.38 0.4
-
 3-deoxy-D-manno-octulosonate at pH 7.6, temperature not specified in the publication Escherichia coli
2.7.7.38 2.6
-
 8-azido-3,8-dideoxy-D-manno-oct-2-ulosonate at pH 7.6, temperature not specified in the publication Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.38 cytoplasm
-
 Escherichia coli 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.38 Mg2+ required Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Escherichia coli
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.38 Escherichia coli P04951
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Escherichia coli diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 ?
2.7.7.38 CTP + 8-azido-3,8-dideoxy-D-manno-oct-2-ulosonate the enzyme does not efficiently recognize azido-3,8-dideoxy-D-manno-oct-2-ulosonate as a substrate Escherichia coli diphosphate + CMP-azido-3,8-dideoxy-D-manno-oct-2-ulosonate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.38 3-deoxy-D-manno-octulosonate cytidylyltransferase
-
 Escherichia coli
2.7.7.38 CKS
-
 Escherichia coli
2.7.7.38 CMP-KDO synthetase
-
 Escherichia coli
2.7.7.38 Kdo cytidylyltransferase
-
 Escherichia coli
2.7.7.38 KdsB
-
 Escherichia coli

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.7.38 1.21
-
 3-deoxy-D-manno-octulosonate at pH 7.6, temperature not specified in the publication Escherichia coli
2.7.7.38 1.36
-
 8-azido-3,8-dideoxy-D-manno-oct-2-ulosonate at pH 7.6, temperature not specified in the publication Escherichia coli

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.7.7.38 0.5
-
 8-azido-3,8-dideoxy-D-manno-oct-2-ulosonate at pH 7.6, temperature not specified in the publication Escherichia coli
2.7.7.38 3
-
 3-deoxy-D-manno-octulosonate at pH 7.6, temperature not specified in the publication Escherichia coli