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Literature summary extracted from

  • Cho, K.H.; Tryon, R.G.; Kim, J.H.
    Screening for diguanylate cyclase (DGC) inhibitors mitigating bacterial biofilm formation (2020), Front. Chem., 8, 264 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.65 2',3'-O-[4-(dihydroxyiminio)-2,6-dinitrocyclohexa-2,5-diene-1,1-diyl]guanosine 5'-triphosphate
-
 Caulobacter vibrioides
2.7.7.65 2',3'-O-[4-(dihydroxyiminio)-2,6-dinitrocyclohexa-2,5-diene-1,1-diyl]guanosine 5'-triphosphate
-
 Clostridioides difficile
2.7.7.65 2',3'-O-[4-(dihydroxyiminio)-2,6-dinitrocyclohexa-2,5-diene-1,1-diyl]guanosine 5'-triphosphate
-
 Komagataeibacter xylinus
2.7.7.65 2',3'-O-[4-(dihydroxyiminio)-2,6-dinitrocyclohexa-2,5-diene-1,1-diyl]guanosine 5'-triphosphate
-
 Pseudomonas aeruginosa
2.7.7.65 2',3'-O-[4-(dihydroxyiminio)-2,6-dinitrocyclohexa-2,5-diene-1,1-diyl]guanosine 5'-triphosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 2',3'-O-[4-(dihydroxyiminio)-2,6-dinitrocyclohexa-2,5-diene-1,1-diyl]guanosine 5'-triphosphate
-
 Synechocystis sp. PCC 6803
2.7.7.65 2',3'-O-[4-(dihydroxyiminio)-2,6-dinitrocyclohexa-2,5-diene-1,1-diyl]guanosine 5'-triphosphate
-
 Vibrio cholerae serotype O1
2.7.7.65 2'-O-[2-(methylamino)benzoyl]guanosine 5'-(gammaS)triphosphate
-
 Caulobacter vibrioides
2.7.7.65 2'-O-[2-(methylamino)benzoyl]guanosine 5'-(gammaS)triphosphate
-
 Clostridioides difficile
2.7.7.65 2'-O-[2-(methylamino)benzoyl]guanosine 5'-(gammaS)triphosphate
-
 Komagataeibacter xylinus
2.7.7.65 2'-O-[2-(methylamino)benzoyl]guanosine 5'-(gammaS)triphosphate
-
 Pseudomonas aeruginosa
2.7.7.65 2'-O-[2-(methylamino)benzoyl]guanosine 5'-(gammaS)triphosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 2'-O-[2-(methylamino)benzoyl]guanosine 5'-(gammaS)triphosphate
-
 Synechocystis sp. PCC 6803
2.7.7.65 2'-O-[2-(methylamino)benzoyl]guanosine 5'-(gammaS)triphosphate
-
 Vibrio cholerae serotype O1
2.7.7.65 2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate
-
 Caulobacter vibrioides
2.7.7.65 2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate
-
 Clostridioides difficile
2.7.7.65 2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate
-
 Komagataeibacter xylinus
2.7.7.65 2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate
-
 Pseudomonas aeruginosa
2.7.7.65 2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate
-
 Synechocystis sp. PCC 6803
2.7.7.65 2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate
-
 Vibrio cholerae serotype O1
2.7.7.65 2-hydroxy-5-[(E)-[4-[(pyridin-2-yl)sulfamoyl]phenyl]diazenyl]benzoic acid
-
 Caulobacter vibrioides
2.7.7.65 2-hydroxy-5-[(E)-[4-[(pyridin-2-yl)sulfamoyl]phenyl]diazenyl]benzoic acid
-
 Clostridioides difficile
2.7.7.65 2-hydroxy-5-[(E)-[4-[(pyridin-2-yl)sulfamoyl]phenyl]diazenyl]benzoic acid
-
 Komagataeibacter xylinus
2.7.7.65 2-hydroxy-5-[(E)-[4-[(pyridin-2-yl)sulfamoyl]phenyl]diazenyl]benzoic acid
-
 Pseudomonas aeruginosa
2.7.7.65 2-hydroxy-5-[(E)-[4-[(pyridin-2-yl)sulfamoyl]phenyl]diazenyl]benzoic acid
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 2-hydroxy-5-[(E)-[4-[(pyridin-2-yl)sulfamoyl]phenyl]diazenyl]benzoic acid
-
 Synechocystis sp. PCC 6803
2.7.7.65 2-hydroxy-5-[(E)-[4-[(pyridin-2-yl)sulfamoyl]phenyl]diazenyl]benzoic acid
-
 Vibrio cholerae serotype O1
2.7.7.65 3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucuronopyranosyl soyasapogenol B 22-O-alpha-D-glucopyranoside
-
 Caulobacter vibrioides
2.7.7.65 3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucuronopyranosyl soyasapogenol B 22-O-alpha-D-glucopyranoside
-
 Clostridioides difficile
2.7.7.65 3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucuronopyranosyl soyasapogenol B 22-O-alpha-D-glucopyranoside
-
 Komagataeibacter xylinus
2.7.7.65 3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucuronopyranosyl soyasapogenol B 22-O-alpha-D-glucopyranoside
-
 Pseudomonas aeruginosa
2.7.7.65 3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucuronopyranosyl soyasapogenol B 22-O-alpha-D-glucopyranoside
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucuronopyranosyl soyasapogenol B 22-O-alpha-D-glucopyranoside
-
 Synechocystis sp. PCC 6803
2.7.7.65 3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucuronopyranosyl soyasapogenol B 22-O-alpha-D-glucopyranoside
-
 Vibrio cholerae serotype O1
2.7.7.65 3-O-alpha-L-rhamnopyronosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-gluconopyranosyl soyasapogenol B 22-o-alpha-D-glucopyranoside potent non-competitive inhibitor in vitro, not membrane-permeable Komagataeibacter xylinus
2.7.7.65 4-(2,5-dimethylphenoxy)-N-(4-morpholin-4-ylphenyl)butanamide
-
 Caulobacter vibrioides
2.7.7.65 4-(2,5-dimethylphenoxy)-N-(4-morpholin-4-ylphenyl)butanamide
-
 Clostridioides difficile
2.7.7.65 4-(2,5-dimethylphenoxy)-N-(4-morpholin-4-ylphenyl)butanamide
-
 Komagataeibacter xylinus
2.7.7.65 4-(2,5-dimethylphenoxy)-N-(4-morpholin-4-ylphenyl)butanamide
-
 Pseudomonas aeruginosa
2.7.7.65 4-(2,5-dimethylphenoxy)-N-(4-morpholin-4-ylphenyl)butanamide
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 4-(2,5-dimethylphenoxy)-N-(4-morpholin-4-ylphenyl)butanamide
-
 Synechocystis sp. PCC 6803
2.7.7.65 4-(2,5-dimethylphenoxy)-N-(4-morpholin-4-ylphenyl)butanamide
-
 Vibrio cholerae serotype O1
2.7.7.65 4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1-sulfonohydrazide
-
 Caulobacter vibrioides
2.7.7.65 4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1-sulfonohydrazide
-
 Clostridioides difficile
2.7.7.65 4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1-sulfonohydrazide
-
 Komagataeibacter xylinus
2.7.7.65 4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1-sulfonohydrazide
-
 Pseudomonas aeruginosa
2.7.7.65 4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1-sulfonohydrazide
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1-sulfonohydrazide
-
 Synechocystis sp. PCC 6803
2.7.7.65 4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1-sulfonohydrazide
-
 Vibrio cholerae serotype O1
2.7.7.65 9-(3-[4-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl]propyl)-6-chloro-9H-purin-2-amine
-
 Caulobacter vibrioides
2.7.7.65 9-(3-[4-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl]propyl)-6-chloro-9H-purin-2-amine
-
 Clostridioides difficile
2.7.7.65 9-(3-[4-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl]propyl)-6-chloro-9H-purin-2-amine
-
 Komagataeibacter xylinus
2.7.7.65 9-(3-[4-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl]propyl)-6-chloro-9H-purin-2-amine
-
 Pseudomonas aeruginosa
2.7.7.65 9-(3-[4-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl]propyl)-6-chloro-9H-purin-2-amine
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 9-(3-[4-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl]propyl)-6-chloro-9H-purin-2-amine
-
 Synechocystis sp. PCC 6803
2.7.7.65 9-(3-[4-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl]propyl)-6-chloro-9H-purin-2-amine
-
 Vibrio cholerae serotype O1
2.7.7.65 cyclic di-3',5'-(2'-fluoroguanylate)
-
 Caulobacter vibrioides
2.7.7.65 cyclic di-3',5'-(2'-fluoroguanylate)
-
 Clostridioides difficile
2.7.7.65 cyclic di-3',5'-(2'-fluoroguanylate)
-
 Komagataeibacter xylinus
2.7.7.65 cyclic di-3',5'-(2'-fluoroguanylate)
-
 Pseudomonas aeruginosa
2.7.7.65 cyclic di-3',5'-(2'-fluoroguanylate)
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 cyclic di-3',5'-(2'-fluoroguanylate)
-
 Synechocystis sp. PCC 6803
2.7.7.65 cyclic di-3',5'-(2'-fluoroguanylate)
-
 Vibrio cholerae serotype O1
2.7.7.65 cyclic di-3',5'-inosinylic acid
-
 Caulobacter vibrioides
2.7.7.65 cyclic di-3',5'-inosinylic acid
-
 Clostridioides difficile
2.7.7.65 cyclic di-3',5'-inosinylic acid
-
 Komagataeibacter xylinus
2.7.7.65 cyclic di-3',5'-inosinylic acid
-
 Pseudomonas aeruginosa
2.7.7.65 cyclic di-3',5'-inosinylic acid
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 cyclic di-3',5'-inosinylic acid
-
 Synechocystis sp. PCC 6803
2.7.7.65 cyclic di-3',5'-inosinylic acid
-
 Vibrio cholerae serotype O1
2.7.7.65 cyclo-di-GMP
-
 Synechocystis sp. PCC 6803
2.7.7.65 cyclo-di-inosinylic acid
-
 Synechocystis sp. PCC 6803
2.7.7.65 ebselen
-
 Caulobacter vibrioides
2.7.7.65 ebselen
-
 Clostridioides difficile
2.7.7.65 ebselen
-
 Komagataeibacter xylinus
2.7.7.65 ebselen
-
 Pseudomonas aeruginosa
2.7.7.65 ebselen
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 ebselen
-
 Synechocystis sp. PCC 6803
2.7.7.65 ebselen
-
 Vibrio cholerae serotype O1
2.7.7.65 eprosartan
-
 Caulobacter vibrioides
2.7.7.65 eprosartan
-
 Clostridioides difficile
2.7.7.65 eprosartan
-
 Komagataeibacter xylinus
2.7.7.65 eprosartan
-
 Pseudomonas aeruginosa
2.7.7.65 eprosartan
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 eprosartan
-
 Synechocystis sp. PCC 6803
2.7.7.65 eprosartan
-
 Vibrio cholerae serotype O1
2.7.7.65 additional information screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2' (3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases; screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2' (3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases Caulobacter vibrioides
2.7.7.65 additional information screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2' (3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases Clostridioides difficile
2.7.7.65 additional information screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2'(3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases Komagataeibacter xylinus
2.7.7.65 additional information screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2' (3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases; screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2'(3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases Pseudomonas aeruginosa
2.7.7.65 additional information screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2' (3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 additional information screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2'(3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases Synechocystis sp. PCC 6803
2.7.7.65 additional information screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2' (3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases Vibrio cholerae serotype O1
2.7.7.65 N'-((1E)-(4-ethoxy-3-[(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)methylphenyl)methylene)]-3,4,5-trihydroxybenzohydrazide LP3134; LP3134 Caulobacter vibrioides
2.7.7.65 N'-((1E)-(4-ethoxy-3-[(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)methylphenyl)methylene)]-3,4,5-trihydroxybenzohydrazide LP3134 Clostridioides difficile
2.7.7.65 N'-((1E)-(4-ethoxy-3-[(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)methylphenyl)methylene)]-3,4,5-trihydroxybenzohydrazide LP3134 Komagataeibacter xylinus
2.7.7.65 N'-((1E)-(4-ethoxy-3-[(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)methylphenyl)methylene)]-3,4,5-trihydroxybenzohydrazide LP3134; LP3134 Pseudomonas aeruginosa
2.7.7.65 N'-((1E)-(4-ethoxy-3-[(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)methylphenyl)methylene)]-3,4,5-trihydroxybenzohydrazide LP3134 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 N'-((1E)-(4-ethoxy-3-[(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)methylphenyl)methylene)]-3,4,5-trihydroxybenzohydrazide LP3134 Synechocystis sp. PCC 6803
2.7.7.65 N'-((1E)-(4-ethoxy-3-[(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)methylphenyl)methylene)]-3,4,5-trihydroxybenzohydrazide LP3134 Vibrio cholerae serotype O1
2.7.7.65 N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-4-methyl-3-nitrobenzene-1-sulfonohydrazide
-
 Caulobacter vibrioides
2.7.7.65 N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-4-methyl-3-nitrobenzene-1-sulfonohydrazide
-
 Clostridioides difficile
2.7.7.65 N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-4-methyl-3-nitrobenzene-1-sulfonohydrazide
-
 Komagataeibacter xylinus
2.7.7.65 N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-4-methyl-3-nitrobenzene-1-sulfonohydrazide
-
 Pseudomonas aeruginosa
2.7.7.65 N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-4-methyl-3-nitrobenzene-1-sulfonohydrazide
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-4-methyl-3-nitrobenzene-1-sulfonohydrazide
-
 Synechocystis sp. PCC 6803
2.7.7.65 N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-4-methyl-3-nitrobenzene-1-sulfonohydrazide
-
 Vibrio cholerae serotype O1
2.7.7.65 N-(4-anilinophenyl)benzamide
-
 Caulobacter vibrioides
2.7.7.65 N-(4-anilinophenyl)benzamide
-
 Clostridioides difficile
2.7.7.65 N-(4-anilinophenyl)benzamide
-
 Komagataeibacter xylinus
2.7.7.65 N-(4-anilinophenyl)benzamide
-
 Pseudomonas aeruginosa
2.7.7.65 N-(4-anilinophenyl)benzamide
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 N-(4-anilinophenyl)benzamide
-
 Synechocystis sp. PCC 6803
2.7.7.65 N-(4-anilinophenyl)benzamide
-
 Vibrio cholerae serotype O1
2.7.7.65 [2- oxo-2-(2-oxopyrrolidin-1-yl)ethyl] 1,3-benzothiazole-6-carboxylate
-
 Caulobacter vibrioides
2.7.7.65 [2- oxo-2-(2-oxopyrrolidin-1-yl)ethyl] 1,3-benzothiazole-6-carboxylate
-
 Clostridioides difficile
2.7.7.65 [2- oxo-2-(2-oxopyrrolidin-1-yl)ethyl] 1,3-benzothiazole-6-carboxylate
-
 Komagataeibacter xylinus
2.7.7.65 [2- oxo-2-(2-oxopyrrolidin-1-yl)ethyl] 1,3-benzothiazole-6-carboxylate
-
 Pseudomonas aeruginosa
2.7.7.65 [2- oxo-2-(2-oxopyrrolidin-1-yl)ethyl] 1,3-benzothiazole-6-carboxylate
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 [2- oxo-2-(2-oxopyrrolidin-1-yl)ethyl] 1,3-benzothiazole-6-carboxylate
-
 Synechocystis sp. PCC 6803
2.7.7.65 [2- oxo-2-(2-oxopyrrolidin-1-yl)ethyl] 1,3-benzothiazole-6-carboxylate
-
 Vibrio cholerae serotype O1

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.65 2 GTP Pseudomonas aeruginosa
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Caulobacter vibrioides
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Komagataeibacter xylinus
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Synechocystis sp. PCC 6803
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Clostridioides difficile
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Salmonella enterica subsp. enterica serovar Typhimurium
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Vibrio cholerae serotype O1
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Caulobacter vibrioides CB15N
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Pseudomonas aeruginosa ATCC 15692
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Caulobacter vibrioides NA1000
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Pseudomonas aeruginosa 1C
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Pseudomonas aeruginosa PRS 101
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Pseudomonas aeruginosa DSM 22644
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Pseudomonas aeruginosa CIP 104116
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Pseudomonas aeruginosa LMG 12228
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Vibrio cholerae serotype O1 El Tor Inaba N16961
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Pseudomonas aeruginosa JCM 14847
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP Vibrio cholerae serotype O1 ATCC 39315
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.65 Caulobacter vibrioides A0A0H3CCZ8 Caulobacter crescentus
-
2.7.7.65 Caulobacter vibrioides B8GZM2
-
-
2.7.7.65 Caulobacter vibrioides CB15N A0A0H3CCZ8 Caulobacter crescentus
-
2.7.7.65 Caulobacter vibrioides NA1000 A0A0H3CCZ8 Caulobacter crescentus
-
2.7.7.65 Caulobacter vibrioides NA1000 B8GZM2
-
-
2.7.7.65 Clostridioides difficile A0A170Y3L9 Peptoclostridium difficile or Clostridium difficile
-
2.7.7.65 Komagataeibacter xylinus O87374 Gluconoacetobacter xylinus or Acetobacter xylinum
-
2.7.7.65 Pseudomonas aeruginosa Q9HT84
-
-
2.7.7.65 Pseudomonas aeruginosa Q9HXT9
-
-
2.7.7.65 Pseudomonas aeruginosa 1C Q9HT84
-
-
2.7.7.65 Pseudomonas aeruginosa 1C Q9HXT9
-
-
2.7.7.65 Pseudomonas aeruginosa ATCC 15692 Q9HT84
-
-
2.7.7.65 Pseudomonas aeruginosa ATCC 15692 Q9HXT9
-
-
2.7.7.65 Pseudomonas aeruginosa CIP 104116 Q9HT84
-
-
2.7.7.65 Pseudomonas aeruginosa CIP 104116 Q9HXT9
-
-
2.7.7.65 Pseudomonas aeruginosa DSM 22644 Q9HT84
-
-
2.7.7.65 Pseudomonas aeruginosa DSM 22644 Q9HXT9
-
-
2.7.7.65 Pseudomonas aeruginosa JCM 14847 Q9HT84
-
-
2.7.7.65 Pseudomonas aeruginosa JCM 14847 Q9HXT9
-
-
2.7.7.65 Pseudomonas aeruginosa LMG 12228 Q9HT84
-
-
2.7.7.65 Pseudomonas aeruginosa LMG 12228 Q9HXT9
-
-
2.7.7.65 Pseudomonas aeruginosa PRS 101 Q9HT84
-
-
2.7.7.65 Pseudomonas aeruginosa PRS 101 Q9HXT9
-
-
2.7.7.65 Salmonella enterica subsp. enterica serovar Typhimurium Q8ZNT5
-
-
2.7.7.65 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 Q8ZNT5
-
-
2.7.7.65 Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 Q8ZNT5
-
-
2.7.7.65 Synechocystis sp. PCC 6803 P73272
-
-
2.7.7.65 Vibrio cholerae serotype O1 Q9KKZ4
-
-
2.7.7.65 Vibrio cholerae serotype O1 ATCC 39315 Q9KKZ4
-
-
2.7.7.65 Vibrio cholerae serotype O1 El Tor Inaba N16961 Q9KKZ4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.65 2 GTP
-
 Pseudomonas aeruginosa 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Caulobacter vibrioides 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Komagataeibacter xylinus 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Synechocystis sp. PCC 6803 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Clostridioides difficile 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Vibrio cholerae serotype O1 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The DgcP of Caulobacter crescentus binds dimeric c-di-GMP at an allosteric site I-site that is characterized by the RxxD motif. Binding of cyclic-di-GMP at the I-site accounts for a strong non-competitive product inhibition, which establishes a limit on the cellular c-di-GMP concentration Caulobacter vibrioides 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Pseudomonas aeruginosa 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Komagataeibacter xylinus 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Synechocystis sp. PCC 6803 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Clostridioides difficile 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Salmonella enterica subsp. enterica serovar Typhimurium 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Vibrio cholerae serotype O1 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Caulobacter vibrioides CB15N 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Pseudomonas aeruginosa ATCC 15692 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Pseudomonas aeruginosa ATCC 15692 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Caulobacter vibrioides NA1000 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The DgcP of Caulobacter crescentus binds dimeric c-di-GMP at an allosteric site I-site that is characterized by the RxxD motif. Binding of cyclic-di-GMP at the I-site accounts for a strong non-competitive product inhibition, which establishes a limit on the cellular c-di-GMP concentration Caulobacter vibrioides NA1000 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Pseudomonas aeruginosa 1C 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Pseudomonas aeruginosa 1C 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Pseudomonas aeruginosa PRS 101 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Pseudomonas aeruginosa PRS 101 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Pseudomonas aeruginosa DSM 22644 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Pseudomonas aeruginosa DSM 22644 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Pseudomonas aeruginosa CIP 104116 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Pseudomonas aeruginosa CIP 104116 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Pseudomonas aeruginosa LMG 12228 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Pseudomonas aeruginosa LMG 12228 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Vibrio cholerae serotype O1 El Tor Inaba N16961 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Vibrio cholerae serotype O1 El Tor Inaba N16961 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Pseudomonas aeruginosa JCM 14847 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Pseudomonas aeruginosa JCM 14847 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP
-
 Vibrio cholerae serotype O1 ATCC 39315 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2.7.7.65 2 GTP the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer) Vibrio cholerae serotype O1 ATCC 39315 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.65 DGC
-
 Pseudomonas aeruginosa
2.7.7.65 DGC
-
 Caulobacter vibrioides
2.7.7.65 DGC
-
 Komagataeibacter xylinus
2.7.7.65 DGC
-
 Synechocystis sp. PCC 6803
2.7.7.65 DGC
-
 Clostridioides difficile
2.7.7.65 DGC
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 DGC
-
 Vibrio cholerae serotype O1
2.7.7.65 Dgc1
-
 Komagataeibacter xylinus
2.7.7.65 DgcA
-
 Caulobacter vibrioides
2.7.7.65 DgcP
-
 Pseudomonas aeruginosa
2.7.7.65 PleD
-
 Caulobacter vibrioides
2.7.7.65 Slr1143
-
 Synechocystis sp. PCC 6803
2.7.7.65 WspR
-
 Pseudomonas aeruginosa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.7.65 0.005
-
 pH and temperature not specified in the publication Komagataeibacter xylinus 3-O-alpha-L-rhamnopyronosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-gluconopyranosyl soyasapogenol B 22-o-alpha-D-glucopyranoside
2.7.7.65 0.011
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa cyclic di-3',5'-(2'-fluoroguanylate)
2.7.7.65 0.1
-
 about, pH and temperature not specified in the publication Synechocystis sp. PCC 6803 cyclic di-3',5'-(2'-fluoroguanylate)

General Information

EC Number General Information Comment Organism
2.7.7.65 malfunction enzyme inhibition by inhibitors causes inhibition of biofilm formation of the organism Pseudomonas aeruginosa
2.7.7.65 malfunction enzyme inhibition by inhibitors causes inhibition of biofilm formation of the organism Caulobacter vibrioides
2.7.7.65 malfunction enzyme inhibition by inhibitors causes inhibition of biofilm formation of the organism Komagataeibacter xylinus
2.7.7.65 malfunction enzyme inhibition by inhibitors causes inhibition of biofilm formation of the organism Synechocystis sp. PCC 6803
2.7.7.65 malfunction enzyme inhibition by inhibitors causes inhibition of biofilm formation of the organism Clostridioides difficile
2.7.7.65 malfunction enzyme inhibition by inhibitors causes inhibition of biofilm formation of the organism Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.65 malfunction enzyme inhibition by inhibitors causes inhibition of biofilm formation of the organism Vibrio cholerae serotype O1
2.7.7.65 physiological function the primary signaling molecule promoting bacterial biofilm formation is the universal second messenger cyclic di-GMP. This dinucleotide predominantly controls the gene expression of motility, adhesins, and capsule production to coordinate biofilm formation. Cyclic di-GMP is synthesized by diguanylate cyclases (DGCs) that have a GGDEF domain and is degraded by phosphodiesterases (PDEs) containing either an EAL or an HD-GYP domain Pseudomonas aeruginosa
2.7.7.65 physiological function the primary signaling molecule promoting bacterial biofilm formation is the universal second messenger cyclic di-GMP. This dinucleotide predominantly controls the gene expression of motility, adhesins, and capsule production to coordinate biofilm formation. Cyclic di-GMP is synthesized by diguanylate cyclases (DGCs) that have a GGDEF domain and is degraded by phosphodiesterases (PDEs) containing either an EAL or an HD-GYP domain Caulobacter vibrioides
2.7.7.65 physiological function the primary signaling molecule promoting bacterial biofilm formation is the universal second messenger cyclic di-GMP. This dinucleotide predominantly controls the gene expression of motility, adhesins, and capsule production to coordinate biofilm formation. Cyclic di-GMP is synthesized by diguanylate cyclases (DGCs) that have a GGDEF domain and is degraded by phosphodiesterases (PDEs) containing either an EAL or an HD-GYP domain Komagataeibacter xylinus
2.7.7.65 physiological function the primary signaling molecule promoting bacterial biofilm formation is the universal second messenger cyclic di-GMP. This dinucleotide predominantly controls the gene expression of motility, adhesins, and capsule production to coordinate biofilm formation. Cyclic di-GMP is synthesized by diguanylate cyclases (DGCs) that have a GGDEF domain and is degraded by phosphodiesterases (PDEs) containing either an EAL or an HD-GYP domain Synechocystis sp. PCC 6803
2.7.7.65 physiological function the primary signaling molecule promoting bacterial biofilm formation is the universal second messenger cyclic di-GMP. This dinucleotide predominantly controls the gene expression of motility, adhesins, and capsule production to coordinate biofilm formation. Cyclic di-GMP is synthesized by diguanylate cyclases (DGCs) that have a GGDEF domain and is degraded by phosphodiesterases (PDEs) containing either an EAL or an HD-GYP domain Vibrio cholerae serotype O1
2.7.7.65 physiological function the primary signaling molecule promoting bacterial biofilm formation is the universal second messenger cyclic di-GMP. This dinucleotide predominantly controls the gene expression of motility, adhesins, and capsule production to coordinate biofilm formation. Cyclic di-GMP is synthesized by diguanylate cyclases (DGCs) that have a GGDEF domain and is degraded by phosphodiesterases (PDEs) containing either an EAL or an HD-GYP domain. The enzyme is important for the organism's biofilm formation ability, which plays a pivotal role in the virulence Pseudomonas aeruginosa
2.7.7.65 physiological function the primary signaling molecule promoting bacterial biofilm formation is the universal second messenger cyclic di-GMP. This dinucleotide predominantly controls the gene expression of motility, adhesins, and capsule production to coordinate biofilm formation. Cyclic di-GMP is synthesized by diguanylate cyclases (DGCs) that have a GGDEF domain and is degraded by phosphodiesterases (PDEs) containing either an EAL or an HD-GYP domain. The enzyme is important for the organism's biofilm formation ability, which plays a pivotal role in the virulence Clostridioides difficile
2.7.7.65 physiological function the primary signaling molecule promoting bacterial biofilm formation is the universal second messenger cyclic di-GMP. This dinucleotide predominantly controls the gene expression of motility, adhesins, and capsule production to coordinate biofilm formation. Cyclic di-GMP is synthesized by diguanylate cyclases (DGCs) that have a GGDEF domain and is degraded by phosphodiesterases (PDEs) containing either an EAL or an HD-GYP domain. The enzyme is important for the organism's biofilm formation ability, which plays a pivotal role in the virulence Salmonella enterica subsp. enterica serovar Typhimurium