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Literature summary extracted from

  • Dobritzsch, D.; Grancharov, K.; Hermsen, C.; Krauss, G.J.; Schaumloeffel, D.
    Inhibitory effect of metals on animal and plant glutathione transferases (2020), J. Trace Elem. Med. Biol., 57, 48-56 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.18 Ag+
-
 Alburnus tarichi
2.5.1.18 Ag+
-
 Meleagris gallopavo
2.5.1.18 Ag+
-
 Oncorhynchus mykiss
2.5.1.18 Al3+ 68% inhibition at 100 mg/kg for male rats, 24% inhibition at 172.5 mg/kg for female rats Rattus norvegicus
2.5.1.18 As3+ 48% inhibition at 0.5 mg/l Laeonereis acuta
2.5.1.18 As3+ 53% inhibition at 10 mg/kg Mus musculus
2.5.1.18 AsO42- 67% inhibition at 0.08 mM Picea abies
2.5.1.18 AsO42- 80% inhibition at 0.05 mM Typha latifolia
2.5.1.18 Cd2+ about 40% inhibition at 0.03 mM Brassica juncea
2.5.1.18 Cd2+ 65% inhibition at 0.1 mM Chelon saliens
2.5.1.18 Cd2+ 35% inhibition at 2.5 mg/kg Mus musculus
2.5.1.18 Cd2+ 53% inhibition at 0.1 mM Oryctolagus cuniculus
2.5.1.18 Cd2+ 90% inhibition at 1 mg/kg Pleuronectes platessa
2.5.1.18 Cd2+ 50% inhibition at 0.05 mM Typha latifolia
2.5.1.18 Cr6+ 58% inhibition at 10 mg/l Pelophylax ridibundus
2.5.1.18 Cu2+ 61% inhibition at 0.1 mM Chelon saliens
2.5.1.18 Cu2+ about 40% inhibition at 0.005 mM Lemna minor
2.5.1.18 Cu2+ about 52% inhibition at 0.008 mM Oryza sativa
2.5.1.18 Cu2+ 37-45% inhibition at 100-800 mg/kg Protaetia brevitarsis
2.5.1.18 dibutyltin
-
 Siganus canaliculatus
2.5.1.18 Hg2+ 70% inhibition at 0.1 mM Chelon saliens
2.5.1.18 Hg2+ 70% inhibition at 0.0009 mg/kg Pacifastacus leniusculus
2.5.1.18 Ni2+ 37% inhibition at 0.5 mM Armoracia rusticana
2.5.1.18 Pb2+ 42% inhibition at 0.1 mM Armoracia rusticana
2.5.1.18 Pb2+ 77% inhibition at 0.02 mg/l in gills, 44% inhibition at 0.02 mg/l in digestive gland Astacus astacus
2.5.1.18 Pb2+ 74% inhibition at 0.1 mM Oryctolagus cuniculus
2.5.1.18 Pb2+ 45% inhibition at 0.05 mM Picea abies
2.5.1.18 Pb2+ 55% inhibition at 0.1% (w/v) Rattus norvegicus
2.5.1.18 Pb2+ 80% inhibition at 0.05 mM Typha latifolia
2.5.1.18 Sb3+ 69% inhibition at 0.1 mM Chelon saliens
2.5.1.18 SeO32- 20% inhibition at 0.1 mg/l Oreochromis mossambicus
2.5.1.18 tributyltin
-
 Rhabdosargus sarba
2.5.1.18 tributyltin 70% inhibition at 0.3 mg/kg Salvelinus alpinus
2.5.1.18 tributyltin
-
 Siganus canaliculatus
2.5.1.18 Triphenyltin
-
 Rhabdosargus sarba
2.5.1.18 Triphenyltin
-
 Siganus canaliculatus
2.5.1.18 Zn2+
-
 Populus sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.18 cytosol
-
 Meleagris gallopavo 5829
-
2.5.1.18 cytosol
-
 Mus musculus 5829
-
2.5.1.18 cytosol
-
 Rattus norvegicus 5829
-
2.5.1.18 cytosol
-
 Oryctolagus cuniculus 5829
-
2.5.1.18 cytosol
-
 Populus sp. 5829
-
2.5.1.18 cytosol
-
 Picea abies 5829
-
2.5.1.18 cytosol
-
 Oryza sativa 5829
-
2.5.1.18 cytosol
-
 Lemna minor 5829
-
2.5.1.18 cytosol
-
 Oncorhynchus mykiss 5829
-
2.5.1.18 cytosol
-
 Astacus astacus 5829
-
2.5.1.18 cytosol
-
 Brassica juncea 5829
-
2.5.1.18 cytosol
-
 Pleuronectes platessa 5829
-
2.5.1.18 cytosol
-
 Typha latifolia 5829
-
2.5.1.18 cytosol
-
 Pacifastacus leniusculus 5829
-
2.5.1.18 cytosol
-
 Oreochromis mossambicus 5829
-
2.5.1.18 cytosol
-
 Armoracia rusticana 5829
-
2.5.1.18 cytosol
-
 Pelophylax ridibundus 5829
-
2.5.1.18 cytosol
-
 Chelon saliens 5829
-
2.5.1.18 cytosol
-
 Alburnus tarichi 5829
-
2.5.1.18 cytosol
-
 Salvelinus alpinus 5829
-
2.5.1.18 cytosol
-
 Protaetia brevitarsis 5829
-
2.5.1.18 cytosol
-
 Laeonereis acuta 5829
-
2.5.1.18 cytosol
-
 Siganus canaliculatus 5829
-
2.5.1.18 cytosol
-
 Rhabdosargus sarba 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.18 Alburnus tarichi
-
-
-
2.5.1.18 Armoracia rusticana
-
-
-
2.5.1.18 Astacus astacus
-
-
-
2.5.1.18 Brassica juncea
-
-
-
2.5.1.18 Chelon saliens
-
-
-
2.5.1.18 Laeonereis acuta
-
-
-
2.5.1.18 Lemna minor
-
-
-
2.5.1.18 Meleagris gallopavo
-
-
-
2.5.1.18 Mus musculus
-
-
-
2.5.1.18 Oncorhynchus mykiss
-
-
-
2.5.1.18 Oreochromis mossambicus
-
-
-
2.5.1.18 Oryctolagus cuniculus
-
-
-
2.5.1.18 Oryza sativa
-
-
-
2.5.1.18 Pacifastacus leniusculus
-
-
-
2.5.1.18 Pelophylax ridibundus
-
-
-
2.5.1.18 Picea abies
-
-
-
2.5.1.18 Pleuronectes platessa
-
-
-
2.5.1.18 Populus sp.
-
-
-
2.5.1.18 Protaetia brevitarsis
-
-
-
2.5.1.18 Rattus norvegicus
-
-
-
2.5.1.18 Rhabdosargus sarba
-
-
-
2.5.1.18 Salvelinus alpinus
-
-
-
2.5.1.18 Siganus canaliculatus
-
-
-
2.5.1.18 Typha latifolia
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.18 digestive gland
-
 Astacus astacus
-
2.5.1.18 erythrocyte
-
 Oncorhynchus mykiss
-
2.5.1.18 gill
-
 Astacus astacus
-
2.5.1.18 hepatopancreas
-
 Pacifastacus leniusculus
-
2.5.1.18 larva
-
 Protaetia brevitarsis
-
2.5.1.18 liver
-
 Meleagris gallopavo
-
2.5.1.18 liver
-
 Chelon saliens
-
2.5.1.18 lung
-
 Oryctolagus cuniculus
-
2.5.1.18 root
-
 Oryza sativa
-
2.5.1.18 seedling
-
 Oryza sativa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.18 glutathione + 1,2-dichloro-4-nitrobenzene
-
 Armoracia rusticana ?
-
 ?
2.5.1.18 glutathione + 1,2-epoxy-3-(4-nitrophenoxy)-propane
-
 Picea abies ?
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Meleagris gallopavo chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Mus musculus chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Rattus norvegicus chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Oryctolagus cuniculus chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Populus sp. chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Oryza sativa chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Lemna minor chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Oncorhynchus mykiss chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Astacus astacus chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Brassica juncea chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Pleuronectes platessa chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Typha latifolia chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Pacifastacus leniusculus chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Oreochromis mossambicus chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Pelophylax ridibundus chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Chelon saliens chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Alburnus tarichi chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Salvelinus alpinus chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Protaetia brevitarsis chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Laeonereis acuta chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Siganus canaliculatus chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Rhabdosargus sarba chloride + 2,4-dinitrophenyl-glutathione
-
 ?
2.5.1.18 glutathione + ethacrynic acid
-
 Chelon saliens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.18 glutathione S-transferase
-
 Meleagris gallopavo
2.5.1.18 glutathione S-transferase
-
 Mus musculus
2.5.1.18 glutathione S-transferase
-
 Rattus norvegicus
2.5.1.18 glutathione S-transferase
-
 Oryctolagus cuniculus
2.5.1.18 glutathione S-transferase
-
 Populus sp.
2.5.1.18 glutathione S-transferase
-
 Picea abies
2.5.1.18 glutathione S-transferase
-
 Oryza sativa
2.5.1.18 glutathione S-transferase
-
 Lemna minor
2.5.1.18 glutathione S-transferase
-
 Oncorhynchus mykiss
2.5.1.18 glutathione S-transferase
-
 Astacus astacus
2.5.1.18 glutathione S-transferase
-
 Brassica juncea
2.5.1.18 glutathione S-transferase
-
 Pleuronectes platessa
2.5.1.18 glutathione S-transferase
-
 Typha latifolia
2.5.1.18 glutathione S-transferase
-
 Pacifastacus leniusculus
2.5.1.18 glutathione S-transferase
-
 Oreochromis mossambicus
2.5.1.18 glutathione S-transferase
-
 Armoracia rusticana
2.5.1.18 glutathione S-transferase
-
 Pelophylax ridibundus
2.5.1.18 glutathione S-transferase
-
 Chelon saliens
2.5.1.18 glutathione S-transferase
-
 Alburnus tarichi
2.5.1.18 glutathione S-transferase
-
 Salvelinus alpinus
2.5.1.18 glutathione S-transferase
-
 Protaetia brevitarsis
2.5.1.18 glutathione S-transferase
-
 Laeonereis acuta
2.5.1.18 glutathione S-transferase
-
 Siganus canaliculatus
2.5.1.18 glutathione S-transferase
-
 Rhabdosargus sarba
2.5.1.18 GST
-
 Meleagris gallopavo
2.5.1.18 GST
-
 Mus musculus
2.5.1.18 GST
-
 Rattus norvegicus
2.5.1.18 GST
-
 Oryctolagus cuniculus
2.5.1.18 GST
-
 Populus sp.
2.5.1.18 GST
-
 Picea abies
2.5.1.18 GST
-
 Oryza sativa
2.5.1.18 GST
-
 Lemna minor
2.5.1.18 GST
-
 Oncorhynchus mykiss
2.5.1.18 GST
-
 Astacus astacus
2.5.1.18 GST
-
 Brassica juncea
2.5.1.18 GST
-
 Pleuronectes platessa
2.5.1.18 GST
-
 Typha latifolia
2.5.1.18 GST
-
 Pacifastacus leniusculus
2.5.1.18 GST
-
 Oreochromis mossambicus
2.5.1.18 GST
-
 Armoracia rusticana
2.5.1.18 GST
-
 Pelophylax ridibundus
2.5.1.18 GST
-
 Chelon saliens
2.5.1.18 GST
-
 Alburnus tarichi
2.5.1.18 GST
-
 Salvelinus alpinus
2.5.1.18 GST
-
 Protaetia brevitarsis
2.5.1.18 GST
-
 Laeonereis acuta
2.5.1.18 GST
-
 Siganus canaliculatus
2.5.1.18 GST
-
 Rhabdosargus sarba

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.5.1.18 0.0004
-
 pH and temperature not specified in the publication Meleagris gallopavo Ag+
2.5.1.18 0.00092
-
 pH and temperature not specified in the publication Siganus canaliculatus tributyltin
2.5.1.18 0.0018
-
 pH and temperature not specified in the publication Rhabdosargus sarba Triphenyltin
2.5.1.18 0.0032
-
 pH and temperature not specified in the publication Siganus canaliculatus dibutyltin
2.5.1.18 0.0035
-
 pH and temperature not specified in the publication Rhabdosargus sarba tributyltin
2.5.1.18 0.004
-
 pH and temperature not specified in the publication Siganus canaliculatus Triphenyltin
2.5.1.18 0.011
-
 pH and temperature not specified in the publication Alburnus tarichi Ag+
2.5.1.18 0.035
-
 pH and temperature not specified in the publication Oncorhynchus mykiss Ag+
2.5.1.18 0.05
-
 pH and temperature not specified in the publication Typha latifolia Cd2+