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Literature summary extracted from

  • Magalhaes, J.; Franko, N.; Annunziato, G.; Welch, M.; Dolan, S.K.; Bruno, A.; Mozzarelli, A.; Armao, S.; Jirgensons, A.; Pieroni, M.; Costantino, G.; Campanini, B.
    Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand-based drug design (2018), J. Enzyme Inhib. Med. Chem., 33, 1444-1452 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.47 1-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid 9% inhibition at 1 microM, 56% inhibition at 1 mM Salmonella enterica subsp. enterica serovar Typhimurium
2.5.1.47 1-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid 8% inhibition at 1 microM, 95% inhibition at 1 mM; 8% inhibition at 1 microM, 95% inhibition at 1 mM Salmonella enterica subsp. enterica serovar Typhimurium
2.5.1.47 1-phenyl-1H-pyrazole-5-carboxylic acid 11% inhibition at 1 microM, 65% inhibition at 1 mM Salmonella enterica subsp. enterica serovar Typhimurium
2.5.1.47 1H-pyrazole-5-carboxylic acid 9% inhibition at 1 microM, 94% inhibition at 1 mM Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.47 Salmonella enterica subsp. enterica serovar Typhimurium P0A1E3 isoform CysK
-
2.5.1.47 Salmonella enterica subsp. enterica serovar Typhimurium P29848 isoform CysM
-

Synonyms

EC Number Synonyms Comment Organism
2.5.1.47 cysK
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.5.1.47 CysM
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.5.1.47 cysteine synthase A
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.5.1.47 cysteine synthase B
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.5.1.47 OASS-A
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.5.1.47 OASS-B
-
 Salmonella enterica subsp. enterica serovar Typhimurium