EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.7.48 | nsp7 | the nsp12 (RdRp) catalyzes the synthesis of a complementary RNA strand using the virus RNA template with the assistance of nsp7 and nsp8 as cofactors | Severe acute respiratory syndrome coronavirus 2 | |
2.7.7.48 | nsp8 | the nsp12 (RdRp) catalyzes the synthesis of a complementary RNA strand using the virus RNA template with the assistance of nsp7 and nsp8 as cofactors | Severe acute respiratory syndrome coronavirus 2 |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.7.48 | afzelin | strong binding affinity to the enzyme (RdRp) | Severe acute respiratory syndrome coronavirus 2 | |
2.7.7.48 | Astragalin | strong binding affinity to the enzyme (RdRp) | Severe acute respiratory syndrome coronavirus 2 | |
2.7.7.48 | biorobin | strong binding affinity to the enzyme (RdRp) | Severe acute respiratory syndrome coronavirus 2 | |
2.7.7.48 | fisetin | high affinities with the RNA-polymerase active site | Severe acute respiratory syndrome coronavirus 2 | |
2.7.7.48 | kaempferol | strong binding affinity to the enzyme (RdRp) | Severe acute respiratory syndrome coronavirus 2 | |
2.7.7.48 | Myricitrin | strong binding affinity to the enzyme (RdRp) | Severe acute respiratory syndrome coronavirus 2 | |
2.7.7.48 | quercetin | high affinities with the RNA-polymerase active site; strong binding affinity to the enzyme (RdRp) | Severe acute respiratory syndrome coronavirus 2 | |
2.7.7.48 | quercetin-3'-O-glucuronide | better binding affinities than quercetin | Severe acute respiratory syndrome coronavirus 2 | |
2.7.7.48 | quercetin-3'-O-sulfate | better binding affinities than quercetin | Severe acute respiratory syndrome coronavirus 2 | |
2.7.7.48 | quercetin-3-O-glucoside | strong binding affinity to the enzyme (RdRp) | Severe acute respiratory syndrome coronavirus 2 | |
2.7.7.48 | quercetin-3-O-glucuronide | better binding affinities than quercetin | Severe acute respiratory syndrome coronavirus 2 | |
2.7.7.48 | quercetin-3-O-rutinoside | i.e. rutin, most active compared to all quercetin derivatives | Severe acute respiratory syndrome coronavirus 2 | |
2.7.7.48 | quercetin-7-O-glucuronide | better binding affinities than quercetin | Severe acute respiratory syndrome coronavirus 2 | |
2.7.7.48 | quercetin-7-O-sulfate | better binding affinities than quercetin | Severe acute respiratory syndrome coronavirus 2 | |
2.7.7.48 | quercitrin | strong binding affinity to the enzyme (RdRp) | Severe acute respiratory syndrome coronavirus 2 |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.7.48 | nucleoside triphosphate + RNAn | Severe acute respiratory syndrome coronavirus 2 | the nsp12 (RdRp) is a central component of SARS-CoV-2 replication/transcription machinery. It catalyzes the synthesis of a complementary RNA strand using the virus RNA template with the assistance of nsp7 and nsp8 as cofactors | diphosphate + RNAn+1 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.7.48 | Severe acute respiratory syndrome coronavirus 2 | P0DTD1 | replicase polyprotein 1ab; SARS-CoV-2 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.7.48 | nucleoside triphosphate + RNAn | - |
Severe acute respiratory syndrome coronavirus 2 | diphosphate + RNAn+1 | - |
? | |
2.7.7.48 | nucleoside triphosphate + RNAn | the nsp12 (RdRp) is a central component of SARS-CoV-2 replication/transcription machinery. It catalyzes the synthesis of a complementary RNA strand using the virus RNA template with the assistance of nsp7 and nsp8 as cofactors | Severe acute respiratory syndrome coronavirus 2 | diphosphate + RNAn+1 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.7.48 | nsp12 | - |
Severe acute respiratory syndrome coronavirus 2 |
2.7.7.48 | RDRP | - |
Severe acute respiratory syndrome coronavirus 2 |
2.7.7.48 | RNA-dependent RNA polymerase | - |
Severe acute respiratory syndrome coronavirus 2 |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.7.48 | physiological function | the nsp12 (RdRp) is a central component of SARS-CoV-2 replication/transcription machinery. It catalyzes the synthesis of a complementary RNA strand using the virus RNA template with the assistance of nsp7 and nsp8 as cofactors | Severe acute respiratory syndrome coronavirus 2 |