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Literature summary extracted from

  • Hao, H.; Hao, S.; Chen, H.; Chen, Z.; Zhang, Y.; Wang, J.; Wang, H.; Zhang, B.; Qiu, J.; Deng, F.; Guan, W.
    N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication (2019), Nucleic Acids Res., 47, 362-374 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.348 nucleus
-
 Chlorocebus sabaeus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.348 S-adenosyl-L-methionine + adenine in RNA Chlorocebus sabaeus
-
 S-adenosyl-L-homocysteine + N6-methyladenine in RNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.348 Chlorocebus aethiops
-
-
-
2.1.1.348 Chlorocebus sabaeus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.348 Vero cell
-
 Chlorocebus aethiops
-
2.1.1.348 Vero cell
-
 Chlorocebus sabaeus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.348 S-adenosyl-L-methionine + adenine in RNA
-
 Chlorocebus sabaeus S-adenosyl-L-homocysteine + N6-methyladenine in RNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.348 m6A methyltransferase
-
 Chlorocebus sabaeus
2.1.1.348 METTL3
-
 Chlorocebus aethiops
2.1.1.348 METTL3
-
 Chlorocebus sabaeus

General Information

EC Number General Information Comment Organism
2.1.1.348 drug target m6A modification may be a target for antivirals of enterovirus 71 (EV71) Chlorocebus aethiops
2.1.1.348 malfunction enzyme knockdown results in decreased enterovirus 71 replication Chlorocebus sabaeus
2.1.1.348 physiological function the enzyme (METTL3) interacts with viral RNA-dependent RNA polymerase 3D and induces enhanced sumoylation and ubiquitination of the 3D polymerase that boosts viral replication. The host m6A modification complex interacts with viral proteins to modulate enterovirus 71 (EV71) replication Chlorocebus aethiops
2.1.1.348 physiological function the enzyme interacts with viral RNA-dependent RNA polymerase 3D and induces enhanced sumoylation and ubiquitination of the 3D polymerase that boosts viral replication Chlorocebus sabaeus