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Literature summary extracted from

  • Singh, A.; Rella, A.; Schwacke, J.; Vacchi-Suzzi, C.; Luberto, C.; Del Poeta, M.
    Transmembrane transporter expression regulated by the glucosylceramide pathway in Cryptococcus neoformans (2015), BMC Res. Notes, 8, 861 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.317 Cryptococcus neoformans var. grubii
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 serotype A
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Synonyms

EC Number Synonyms Comment Organism
2.1.1.317 SMT1
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 Cryptococcus neoformans var. grubii

General Information

EC Number General Information Comment Organism
2.1.1.317 malfunction DELTAsmt1 mutants lacking the sphingolipid C9 methyltransferase gene (SMT1) are attenuated in virulence and have a growth defect at 37 °C, in neutral/alkaline pH and 5 % CO2 environments Cryptococcus neoformans var. grubii
2.1.1.317 physiological function the enzyme adds a methyl group to position nine of the sphingosine backbone of ceramide. The sphingolipid glucosylceramide and factors involved in the fungal GlcCer pathways are an integral part of fungal virulence, especially in fungal replication at 37 °C, in neutral/alkaline pH and 5 % CO2 environments (e.g. alveolar spaces) Cryptococcus neoformans var. grubii