EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.1.2.1 | Y55T | the variant tolerates aromatic and aliphatic aldehydes as well as hydroxy- and nitrogen-containing aldehydes as acceptors | Streptococcus thermophilus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.1 | 5,10-methylenetetrahydrofolate + glycine + H2O | Streptococcus thermophilus | - |
tetrahydrofolate + L-serine | - |
r | |
2.1.2.1 | 5,10-methylenetetrahydrofolate + glycine + H2O | Streptococcus thermophilus CNRZ 1066 | - |
tetrahydrofolate + L-serine | - |
r | |
2.1.2.1 | tetrahydrofolate + L-serine | Streptococcus thermophilus | - |
5,10-methylenetetrahydrofolate + glycine + H2O | - |
r | |
2.1.2.1 | tetrahydrofolate + L-serine | Streptococcus thermophilus CNRZ 1066 | - |
5,10-methylenetetrahydrofolate + glycine + H2O | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.2.1 | Streptococcus thermophilus | Q5M0B4 | - |
- |
2.1.2.1 | Streptococcus thermophilus CNRZ 1066 | Q5M0B4 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.1 | 5,10-methylenetetrahydrofolate + glycine + H2O | - |
Streptococcus thermophilus | tetrahydrofolate + L-serine | - |
r | |
2.1.2.1 | 5,10-methylenetetrahydrofolate + glycine + H2O | - |
Streptococcus thermophilus CNRZ 1066 | tetrahydrofolate + L-serine | - |
r | |
2.1.2.1 | D-alanine + (benzyloxy)acetaldehyde + H2O | - |
Streptococcus thermophilus | (3R)-4-(benzyloxy)-3-hydroxy-L-isovaline + (3S)-4-(benzyloxy)-3-hydroxy-L-isovaline | - |
? | |
2.1.2.1 | D-alanine + (benzyloxy)acetaldehyde + H2O | - |
Streptococcus thermophilus CNRZ 1066 | (3R)-4-(benzyloxy)-3-hydroxy-L-isovaline + (3S)-4-(benzyloxy)-3-hydroxy-L-isovaline | - |
? | |
2.1.2.1 | D-alanine + 2-fluorobenzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid + (2S,3R)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid | - |
? | |
2.1.2.1 | D-alanine + 2-fluorobenzaldehyde + H2O | - |
Streptococcus thermophilus CNRZ 1066 | (2S,3S)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid + (2S,3R)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid | - |
? | |
2.1.2.1 | D-alanine + 3-phenylpropanal + H2O | - |
Streptococcus thermophilus | (3S)-3-hydroxy-2-methyl-5-phenyl-L-norvaline + (3R)-3-hydroxy-2-methyl-5-phenyl-L-norvaline | - |
? | |
2.1.2.1 | D-alanine + 3-phenylpropanal + H2O | - |
Streptococcus thermophilus CNRZ 1066 | (3S)-3-hydroxy-2-methyl-5-phenyl-L-norvaline + (3R)-3-hydroxy-2-methyl-5-phenyl-L-norvaline | - |
? | |
2.1.2.1 | D-alanine + 4-(benzyloxy)butanal + H2O | - |
Streptococcus thermophilus | (3R)-3-hydroxy-4-(3-phenylpropoxy)-L-isovaline + (3S)-3-hydroxy-4-(3-phenylpropoxy)-L-isovaline | - |
? | |
2.1.2.1 | D-alanine + 4-chlorobenzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-(4-chlorophenyl)-3-hydroxy-2-methylpropanoic acid + (2S,3R)-2-amino-3-(4-chlorophenyl)-3-hydroxy-2-methylpropanoic acid | - |
? | |
2.1.2.1 | D-alanine + 4-formylphenyl acetate + H2O | - |
Streptococcus thermophilus | (2S,3S)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxy-2-methylpropanoic acid + (2S,3R)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxy-2-methylpropanoic acid | - |
? | |
2.1.2.1 | D-alanine + 4-hydroxybenzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropanoic acid + (2S,3R)-2-amino-3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropanoic acid | - |
? | |
2.1.2.1 | D-alanine + 4-nitrobenzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-hydroxy-2-methyl-3-(4-nitrophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-methyl-3-(4-nitrophenyl)propanoic acid | - |
? | |
2.1.2.1 | D-alanine + benzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-hydroxy-2-methyl-3-phenylpropanoic acid + (2S,3R)-2-amino-3-hydroxy-2-methyl-3-phenylpropanoic acid | - |
? | |
2.1.2.1 | D-alanine + benzyl (2-oxoethyl)carbamate + H2O | - |
Streptococcus thermophilus | (3S)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-L-isovaline + (3R)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-L-isovaline | - |
? | |
2.1.2.1 | D-alanine + benzyl (3-oxopropyl)carbamate + H2O | - |
Streptococcus thermophilus | (3S)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-methyl-L-lysine + (2S,3R)-2-amino-6-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-methylhexanoic acid | - |
? | |
2.1.2.1 | D-alanine + benzyl [(2R)-1-oxopropan-2-yl]carbamate + H2O | - |
Streptococcus thermophilus | (3S)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-methyl-L-lysine + (3R)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-methyl-L-lysine | - |
? | |
2.1.2.1 | D-alanine + benzyl [(2S)-1-oxopropan-2-yl]carbamate + H2O | - |
Streptococcus thermophilus | (3S,4S)-4-([(benzyloxy)carbonyl]amino)-3-hydroxy-2-methyl-L-norvaline + (3R,4S)-4-([(benzyloxy)carbonyl]amino)-3-hydroxy-2-methyl-L-norvaline | - |
? | |
2.1.2.1 | D-alanine + pentafluorobenzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-hydroxy-2-methyl-3-(pentafluorophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-methyl-3-(pentafluorophenyl)propanoic acid | - |
? | |
2.1.2.1 | D-alanine + phenoxyacetaldehyde + H2O | - |
Streptococcus thermophilus | (3R)-3-hydroxy-4-phenoxy-L-isovaline + (3S)-3-hydroxy-4-phenoxy-L-isovaline | - |
? | |
2.1.2.1 | D-alanine + phenylacetaldehyde + H2O | - |
Streptococcus thermophilus | (3S)-3-hydroxy-4-phenyl-L-isovaline + (3R)-3-hydroxy-4-phenyl-L-isovaline | - |
? | |
2.1.2.1 | D-serine + (benzyloxy)acetaldehyde + H2O | - |
Streptococcus thermophilus | (3R)-4-(benzyloxy)-2',3-dihydroxy-L-isovaline + (3S)-4-(benzyloxy)-2',3-dihydroxy-L-isovaline | - |
? | |
2.1.2.1 | D-serine + 2-fluorobenzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-(hydroxymethyl)propanoic acid + (2S,3R)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-(hydroxymethyl)propanoic acid | - |
? | |
2.1.2.1 | D-serine + 3-phenylpropanal + H2O | - |
Streptococcus thermophilus | (3S)-3-hydroxy-2-(hydroxymethyl)-5-phenyl-L-norvaline + (3R)-3-hydroxy-2-(hydroxymethyl)-5-phenyl-L-norvaline | - |
? | |
2.1.2.1 | D-serine + 4-(benzyloxy)butanal + H2O | - |
Streptococcus thermophilus | (3S)-4-[[(benzyloxy)carbonyl]amino]-2',3-dihydroxy-L-isovaline + (3S)-2',3-dihydroxy-4-(3-phenylpropoxy)-L-isovaline | - |
? | |
2.1.2.1 | D-serine + 4-chlorobenzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-(4-chlorophenyl)-3-hydroxy-2-(hydroxymethyl)propanoic acid + (2S,3R)-2-amino-3-(4-chlorophenyl)-3-hydroxy-2-(hydroxymethyl)propanoic acid | - |
? | |
2.1.2.1 | D-serine + 4-formylphenyl acetate + H2O | - |
Streptococcus thermophilus | (2S,3S)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxy-2-(hydroxymethyl)propanoic acid + (2S,3R)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxy-2-(hydroxymethyl)propanoic acid | - |
? | |
2.1.2.1 | D-serine + 4-hydroxybenzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(4-hydroxyphenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(4-hydroxyphenyl)propanoic acid | - |
? | |
2.1.2.1 | D-serine + 4-nitrobenzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(4-nitrophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(4-nitrophenyl)propanoic acid | - |
? | |
2.1.2.1 | D-serine + benzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-phenylpropanoic acid + (2S,3R)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-phenylpropanoic acid | - |
? | |
2.1.2.1 | D-serine + benzyl (2-oxoethyl)carbamate + H2O | - |
Streptococcus thermophilus | (3S)-4-[[(benzyloxy)carbonyl]amino]-2',3-dihydroxy-L-isovaline + (3R)-4-[[(benzyloxy)carbonyl]amino]-2',3-dihydroxy-L-isovaline | - |
? | |
2.1.2.1 | D-serine + benzyl (3-oxopropyl)carbamate + H2O | - |
Streptococcus thermophilus | (3S)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-(hydroxymethyl)-L-lysine + (3R)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-(hydroxymethyl)-L-lysine | - |
? | |
2.1.2.1 | D-serine + benzyl [(2R)-1-oxopropan-2-yl]carbamate + H2O | - |
Streptococcus thermophilus | (3S,4R)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-(hydroxymethyl)-L-norvaline + (3R,4R)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-(hydroxymethyl)-L-norvaline | - |
? | |
2.1.2.1 | D-serine + benzyl [(2S)-1-oxopropan-2-yl]carbamate + H2O | - |
Streptococcus thermophilus | (3S,4S)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-(hydroxymethyl)-L-norvaline + (3R,4S)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-(hydroxymethyl)-L-norvaline | - |
? | |
2.1.2.1 | D-serine + pentafluorobenzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(pentafluorophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(pentafluorophenyl)propanoic acid | - |
? | |
2.1.2.1 | D-serine + phenoxyacetaldehyde + H2O | - |
Streptococcus thermophilus | (3R)-2',3-dihydroxy-4-phenoxy-L-isovaline + (3S)-2',3-dihydroxy-4-phenoxy-L-isovaline | - |
? | |
2.1.2.1 | D-serine + phenylacetaldehyde + H2O | - |
Streptococcus thermophilus | (3S)-2',3-dihydroxy-4-phenyl-L-isovaline + (3R)-2',3-dihydroxy-4-phenyl-L-isovaline | - |
? | |
2.1.2.1 | glycine + (benzyloxy)acetaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3R)-2-amino-4-(benzyloxy)-3-hydroxybutanoic acid + (2S,3S)-2-amino-4-(benzyloxy)-3-hydroxybutanoic acid | - |
? | |
2.1.2.1 | glycine + 2-fluorobenzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-(2-fluorophenyl)-3-hydroxypropanoic acid + (2S,3R)-2-amino-3-(2-fluorophenyl)-3-hydroxypropanoic acid | - |
? | |
2.1.2.1 | glycine + 3-phenylpropanal + H2O | - |
Streptococcus thermophilus | (3S)-3-hydroxy-5-phenyl-L-norvaline + (3R)-3-hydroxy-5-phenyl-L-norvaline | - |
? | |
2.1.2.1 | glycine + 4-(benzyloxy)butanal + H2O | - |
Streptococcus thermophilus | (2S,3R)-2-amino-3-hydroxy-4-(3-phenylpropoxy)butanoic acid + (2S,3S)-2-amino-3-hydroxy-4-(3-phenylpropoxy)butanoic acid | - |
? | |
2.1.2.1 | glycine + 4-chlorobenzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-(4-chlorophenyl)-3-hydroxypropanoic acid + (2S,3R)-2-amino-3-(4-chlorophenyl)-3-hydroxypropanoic acid | - |
? | |
2.1.2.1 | glycine + 4-formylphenyl acetate + H2O | - |
Streptococcus thermophilus | (2S,3S)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxypropanoic acid + (2S,3R)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxypropanoic acid | - |
? | |
2.1.2.1 | glycine + 4-hydroxybenzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-hydroxy-3-(4-hydroxyphenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-3-(4-hydroxyphenyl)propanoic acid | - |
? | |
2.1.2.1 | glycine + 4-nitrobenzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-3-(4-nitrophenyl)propanoic acid | - |
? | |
2.1.2.1 | glycine + benzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid + (2S,3R)-2-amino-3-hydroxy-3-phenylpropanoic acid | - |
? | |
2.1.2.1 | glycine + benzyl (2-oxoethyl)carbamate + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxybutanoic acid + (2S,3R)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxybutanoic acid | - |
? | |
2.1.2.1 | glycine + benzyl (3-oxopropyl)carbamate + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-6-[[(benzyloxy)carbonyl]amino]-3-hydroxyhexanoic acid + (2S,3R)-2-amino-6-[[(benzyloxy)carbonyl]amino]-3-hydroxyhexanoic acid | - |
? | |
2.1.2.1 | glycine + benzyl [(2R)-1-oxopropan-2-yl]carbamate + H2O | - |
Streptococcus thermophilus | (2S,3S,4R)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-methylpentanoic acid + (2S,3S,4R)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxypentanoic acid | - |
? | |
2.1.2.1 | glycine + benzyl [(2S)-1-oxopropan-2-yl]carbamate + H2O | - |
Streptococcus thermophilus | (2S,3R,4S)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxypentanoic acid + (2S,3S,4S)-2-amino-4-[[(benzyloxy)carbonyl]amino]-3-hydroxypentanoic acid | - |
? | |
2.1.2.1 | glycine + pentafluorobenzaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-hydroxy-3-(pentafluorophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-3-(pentafluorophenyl)propanoic acid | - |
? | |
2.1.2.1 | glycine + phenoxyacetaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3R)-2-amino-3-hydroxy-4-phenoxybutanoic acid + (2S,3S)-2-amino-3-hydroxy-4-phenoxybutanoic acid | - |
? | |
2.1.2.1 | glycine + phenylacetaldehyde + H2O | - |
Streptococcus thermophilus | (2S,3S)-2-amino-3-hydroxy-4-phenylbutanoic acid + (2S,3R)-2-amino-3-hydroxy-4-phenylbutanoic acid | - |
? | |
2.1.2.1 | tetrahydrofolate + L-serine | - |
Streptococcus thermophilus | 5,10-methylenetetrahydrofolate + glycine + H2O | - |
r | |
2.1.2.1 | tetrahydrofolate + L-serine | - |
Streptococcus thermophilus CNRZ 1066 | 5,10-methylenetetrahydrofolate + glycine + H2O | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.2.1 | L-serine hydroxymethyltransferase | - |
Streptococcus thermophilus |
2.1.2.1 | SHMT | - |
Streptococcus thermophilus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.1.2.1 | pyridoxal 5'-phosphate | dependent on | Streptococcus thermophilus |