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Literature summary extracted from

  • Estrella, M.A.; Du, J.; Chen, L.; Rath, S.; Prangley, E.; Chitrakar, A.; Aoki, T.; Schedl, P.; Rabinowitz, J.; Korennykh, A.
    The metabolites NADP+ and NADPH are the targets of the circadian protein nocturnin (curled) (2019), Nat. Commun., 10, 2367 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.108
-
 Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.1.3.108 hanging drop vapor diffusion method Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.108 E140A active site mutant, catalytic activity is blocked Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.108 Ca2+ NOCT is inactive in the presence of Zn2+ and Ca2+ presumably due imperfect transition state formed due to a slight size mismatch of these ions Homo sapiens
3.1.3.108 Zn2+ NOCT is inactive in the presence of Zn2+ and Ca2+ presumably due imperfect transition state formed due to a slight size mismatch of these ions Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.108 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.108 Drosophila melanogaster A8JQX3
-
-
3.1.3.108 Homo sapiens Q9UK39
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.108
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.108 A-549 cell
-
 Homo sapiens
-
3.1.3.108 lung epithelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.108 NADP+ + H2O
-
 Homo sapiens NAD+ + phosphate
-
 ?
3.1.3.108 NADP+ + H2O
-
 Drosophila melanogaster NAD+ + phosphate
-
 ?
3.1.3.108 NADPH + H2O
-
 Homo sapiens NADH + phosphate
-
 ?
3.1.3.108 NADPH + H2O
-
 Drosophila melanogaster NADH + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.108 Curled
-
 Drosophila melanogaster
3.1.3.108 NOCT
-
 Homo sapiens
3.1.3.108 nocturnin
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.3.108 physiological function rhythmically expressed protein that regulates metabolism under the control of circadian clock Homo sapiens
3.1.3.108 physiological function rhythmically expressed protein that regulates metabolism under the control of circadian clock Drosophila melanogaster