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Literature summary extracted from

  • Ferreira, N.S.; Engelsby, H.; Neess, D.; Kelly, S.L.; Volpert, G.; Merrill, A.H.; Futerman, A.H.; Faergeman, N.J.
    Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein (2017), J. Biol. Chem., 292, 7588-7597 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.297 acyl-coenzyme A-binding protein increases the activity of ceramide synthase 2 by more than 2fold. The compound binds very-long chain acyl-CoA esters, which is required for its ability to stimulate enzyme activity Mus musculus
2.3.1.298 acyl-coenzyme A-binding protein increases the activity of the enzyme by 7fold Mus musculus
2.3.1.298 additional information high-speed liver cytosol from wild type mice activates enzyme activity, whereas cytosol from acyl-coenzyme A-binding protein knock-out mice does not Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.297 expressed in HEK-293T cells Mus musculus
2.3.1.298 expressed in HEK-293T cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.298 W15R catalytically inactive Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.297 a very-long-chain fatty acyl-CoA + a sphingoid base Mus musculus
-
 a very-long-chain ceramide + CoA
-
 ?
2.3.1.298 an ultra-long-chain fatty acyl-CoA + a sphingoid base Mus musculus
-
 an ultra-long-chain ceramide + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.297 Mus musculus
-
-
-
2.3.1.298 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.298 testis
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.297 a very-long-chain fatty acyl-CoA + a sphingoid base
-
 Mus musculus a very-long-chain ceramide + CoA
-
 ?
2.3.1.297 nervonyl-CoA + sphinganine
-
 Mus musculus CoA + nervonyl-sphinganine
-
 ?
2.3.1.298 an ultra-long-chain fatty acyl-CoA + a sphingoid base
-
 Mus musculus an ultra-long-chain ceramide + CoA
-
 ?
2.3.1.298 hexacosanoyl-CoA + sphinganine main substrate Mus musculus hexacosanoyl ceramide + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.297 ceramide synthase 2
-
 Mus musculus
2.3.1.297 CerS2
-
 Mus musculus
2.3.1.298 CerS3
-
 Mus musculus
2.3.1.298 sphingoid base N-ultra-long-chain fatty acyl-coA transferase
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.3.1.297 Mus musculus ceramide synthase 2 activity is significantly reduced in the testes of acyl-coenzyme A-binding protein-deficient mice down
2.3.1.298 Mus musculus enzyme activity is significantly reduced in the testes of acyl-coenzyme A-binding protein-deficient mice down