Literature summary extracted from

Aoki, J.; Inoue, A.; Makide, K.; Saiki, N.; Arai, H.
Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family (2007), Biochimie, 89, 197-204 .

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.1.1.111	extracellular	-	Homo sapiens	-	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.1.111	Homo sapiens	Q53H76	-	-

General Information

EC Number	General Information	Comment	Organism
3.1.1.111	physiological function	review on extracellular PLA1s including phosphatidylserine-specific PLA1, membrane-associated phosphatidic acid-selective mPA-PLA1alpha and mPA-PLA1beta. The tertiary structures of lipases show two surface loops, the lid and the beta9 loop. The lid and the beta9 loop cover the active site in its closed conformation. Phosphatidylserine-specific PLA1, membrane-associated phosphatidic acid-selective mPA-PLA1alpha and mPA-PLA1beta have short lids and short loops. They specifically hydrolyze phospatidylserine and phosphatidic acid, respectively, producing their corresponding lysophospholipids	Homo sapiens

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Release 2023.1 (January 2023)