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Literature summary extracted from
- A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis (2018), Nat. Chem. Biol., 14, 738-743 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.2.99.24 | expression in Escherichia coli | Papaver somniferum |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.99.24 | 0.022 | - |
salutaridinol 7-O-acetate | allosteric enzyme, Ka value, pH not specified in the publication, temperature not specified in the publication | Papaver somniferum |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.2.99.24 | 40000 | - |
gel filtration | Papaver somniferum |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.99.24 | Papaver somniferum | A0A2U9GGW3 | isoform THS2 | - |
| 4.2.99.24 | Papaver somniferum | A0A2U9GHG9 | isoform THS1 | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.2.99.24 | latex | - |
Papaver somniferum | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.99.24 | salutaridinol 7-O-acetate | - |
Papaver somniferum | thebaine + acetate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.2.99.24 | dimer | 2 * 17000, SDS-PAGE | Papaver somniferum |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.99.24 | THS1 | - |
Papaver somniferum |
| 4.2.99.24 | THS2 | - |
Papaver somniferum |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.2.99.24 | 8 | - |
- |
Papaver somniferum |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 4.2.99.24 | physiological function | suppression of THS transcript abundance causes a substantial reduction in thebaine levels and a significant accumulation of the upstream intermediates salutaridinol and reticuline | Papaver somniferum |
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Release 2023.1 (January 2023)
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